merck millipore,默克密理愽
  • merck millipore,默克密理博,341207,ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem

  • merck millipore,默克密理博,341207,ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem

    产品名称：ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem
    产品型号：341207
    A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells.

    merck millipore,默克密理博,341207,ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,341207,ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₇H₅₈NO₆P70641-51-9
    描述
    概述 A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Promotes apoptosis in mitogen-activated, but not resting, T lymphocytes in a dose- and time-dependent manner. Also promotes rapid and selective apoptosis in human leukemic cells.
    产品目录编号 341207
    品牌系列 Calbiochem®
    同义词 Edelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine
    参考
    参考 Harguindey, J., et al. 2000. Apoptosis 5, 87.
    Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
    Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
    Helfman, D., et al. 1993. Cancer Res. 53, 2955.
    Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
    Powis, G., et al. 1992. Cancer Res. 52, 2835.
    Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.
    产品信息
    CAS号 70641-51-9
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₂₇H₅₈NO₆P
    化学配方 C₂₇H₅₈NO₆P
    Molar Mass 523.7
    可逆 Y
    结构配方图像
    生物信息
    主靶 PI-PLC
    主靶IC50 9.6 µM against phosphatidylinositol-specific phospholipase C (PI-PLC)
    纯度 ≥95% by TLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO, CHCl₃, EtOH, or H₂O
    GHS安全信息
    RTECS YK0718000
    安全信息
    R相 R: 40

    Limited evidence of a carcinogenic effect.
    S相 S: 22-36

    Do not breathe dust.
    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Carcinogenic / Teratogenic
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.

    merck millipore,默克密理博,341207,ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem

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