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品种反应性 主要应用 宿主 格式 抗体类型 R, M WB, IHC R Culture Supernatant Monoclonal Antibody 描述 产品目录编号 MAB5596 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-HCN2 Antibody Alternate Names - Hyperpolarization-activated and cyclic nucleotide-gated channel 2
产品信息 格式 Culture Supernatant 演示 Cultured supernatant containing 0.05% sodium azide. 应用 应用 Anti-HCN2 Antibody is an antibody against HCN2 for use in IH & WB. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Western blot on rat and mouse retina. The antibody recognizes a weak band at ~98 kDa and a stronger band at ~108 kDa in glycosylated protein from a retinal membrane preparation.
Immunohistochemistry on rat and mouse retina.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide from rat HCN2. 宿主 Rat 特异性 HCN2 (Hyperpolarization-activated and cyclic nucleotide-gated channel 2). The antibody recognizes both the glycosyated and deglycosylated form of HCN2. The antibody recognizes a weak band at ~98 kDa and a stronger band at ~108 kDa in glycosylated protein from a retinal membrane preparation. 同种型 IgG1 品种反应性 RatMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001194.3
基因符号 - BCNG2
- HCN2
- BCNG-2
- HAC-1
UniProt编号 - Q9UL51
UniProt汇总 FUNCTION: SwissProt: Q9UL51 # Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity).
SIZE: 889 amino acids; 96950 Da
SUBUNIT: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN1. Interacts with KCNE2 (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Highly expressed throughout the brain. Detected at low levels in heart.
DOMAIN:SwissProt: Q9UL51 The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
SIMILARITY: Belongs to the potassium channel HCN family. & Contains 1 cyclic nucleotide-binding domain.
MISCELLANEOUS: Inhibited by extracellular cesium ions.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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下一件merck millipore产品：merck millipore,默克密理博,04-240,Anti-p27(Kip1) Antibody, clone Y236, rabbit monoclonal
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