merck millipore,默克密理博,MAB1096,Anti-Tumor Necrosis Factor-α Antibody, clone 195

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merck millipore,默克密理博,MAB1096,Anti-Tumor Necrosis Factor-α Antibody, clone 195
产品名称：Anti-Tumor Necrosis Factor-α Antibody, clone 195
产品型号：MAB1096
This Anti-Tumor Necrosis Factor-α Antibody, clone 195 is validated for use in IC, IH, NEUT, WB for the detection of Tumor Necrosis Factor-α.

merck millipore,默克密理博,MAB1096,Anti-Tumor Necrosis Factor-α Antibody, clone 195

产品介绍

merck millipore,默克密理博,MAB1096,Anti-Tumor Necrosis Factor-α Antibody, clone 195

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB, ICC, IHC	M	Purified	Monoclonal Antibody

描述
产品目录编号	MAB1096
Replaces	04-1114
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Tumor Necrosis Factor-α Antibody, clone 195
Alternate Names	TNF-alpha

产品信息
格式	Purified
演示	Purified immunoglobulin. Liquid in 0.01M PBS pH 7.1, 0.15M NaCl containing no preservatives. Sterile filtered.

应用
应用	This Anti-Tumor Necrosis Factor-α Antibody, clone 195 is validated for use in IC, IH, NEUT, WB for the detection of Tumor Necrosis Factor-α.
主要应用	Western Blotting Immunocytochemistry Immunohistochemistry
应用说明	Western Blot Immunocytochemistry Immunohistochemistry Neutralization: 50 ng of TNF-alpha antibody is required for the neutralization of 1 U TNF-alpha. The TNF-alpha-preparation which is used has a specific activity of 2 x 10(7) U/mg protein [cell lytic assay with L929 cells (mouse transformed fibroblasts) and/or WEHJ 164 cells (mouse fibrosarcoma cells)/actinomycin D]. Optimal working dilutions must be determined by end user.

生物信息
免疫原品种	Human, recombinant tumor necrosis factor-alpha produced in E. coli.
克隆	195
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	The antibody reacts with human, natural and recombinant TNF-alpha. lt does not react with human TNF-beta (lymphotoxin). lt does not react with TNF-alpha from mouse, rat, canine, porcine, rhesus-monkey or baboon. SPECIES REACTIVITIES: Not mouse, rat, canine, porcine, baboon or rhesus-monkey.
同种型	IgG3
品种反应性	Human
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_000594.2
Entrez基因汇总	This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
基因符号	TNF-alpha TNF OTTHUMP00000037669 TNFA TNFSF2 cachectin TNF-a Cachectin DIF
非反应性品种	Baboon Canine Mouse Monkey Pig Rat
UniProt编号	P01375
UniProt汇总	FUNCTION: SwissProt: P01375 # Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. SIZE: 233 amino acids; 25644 Da SUBUNIT: Homotrimer. SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. & Tumor necrosis factor, soluble form: Secreted. PTM: The soluble form derives from the membrane form by proteolytic processing. & The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1. DISEASE: SwissProt: P01375 # Cachexia accompanies a variety of diseases, including cancer and infection, and is characterized by general ill health and malnutrition. & Genetic variations in TNF are associated with susceptibility to psoriatic arthritis [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative arthritis) associated with psoriasis. & Genetic variations in TNF are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis requiring liver transplantation. SIMILARITY: SwissProt: P01375 ## Belongs to the tumor necrosis factor family.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Freeze only once.

包装信息
数量	200 µg

merck millipore,默克密理博,MAB1096,Anti-Tumor Necrosis Factor-α Antibody, clone 195

上一件merck millipore产品：merck millipore,默克密理博,04-240,Anti-p27(Kip1) Antibody, clone Y236, rabbit monoclonal
下一件merck millipore产品：merck millipore,默克密理博,MABF507,Anti-CD115 (c-fms) Antibody (mouse), APC, clone AFS98

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