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merck millipore,默克密理博,324888,Epigenetic Multiple Ligand - CAS 1020399-52-3 - Calbiochem
产品名称：Epigenetic Multiple Ligand - CAS 1020399-52-3 - Calbiochem
产品型号：324888
A cell-permeable bis-arylidene compound that acts as an epigenetic multiple ligand (epi-ML) and inhibits substrates processing by several chromatin-associated enzymes.
merck millipore,默克密理博,324888,Epigenetic Multiple Ligand - CAS 1020399-52-3 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₉H₁₂Br₄O₄ 1020399-52-3 描述 概述 A cell-permeable bis-arylidene compound that acts as an epigenetic multiple ligand (epi-ML) and inhibits substrates processing by several chromatin-associated enzymes, including H4/PRMT1 (91% inhibition at 50 µM), H4/RmtA (50% inhibition at 29 µM), H3/p300/CBP (61% inhibition at 50 µM), PABP1/CARM1 (>90% inhibition at 100 µM), H3/SET7 (>90% inhibition at 100 µM), SIRT1/2 (>50% inhibition at 25 µM), although the process of Np13p by PRMT1 is only weakly affected. Shown to induce either apoptosis (28% after 30 h incubation with 25 µM inhibitor) or granulocytic differentiation (100% of non-apoptotic cells after 30 hr incubation with 5 µM inhibitor) among U937 cell population. 产品目录编号 324888 品牌系列 Calbiochem®
同义词 3,5-bis(3,5-Dibromo-4-hydroxybenzylidene)-tetrahydro-2H-pyran-4-one, PRMT Inhibitor IV 参考 参考 Mai, A., et al. 2008. J. Med. Chem. 51, 2279. 产品信息 CAS号 1020399-52-3 形式 Light orange solid Hill配方 C₁₉H₁₂Br₄O₄ 化学配方 C₁₉H₁₂Br₄O₄ Molar Mass 623.9 结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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