merck millipore,默克密理愽
  • merck millipore,默克密理博,324877,Focal Adhesion Kinase Inhibitor I - CAS 4506-66-5 - Calbiochem

  • merck millipore,默克密理博,324877,Focal Adhesion Kinase Inhibitor I - CAS 4506-66-5 - Calbiochem

    产品名称：Focal Adhesion Kinase Inhibitor I - CAS 4506-66-5 - Calbiochem
    产品型号：324877
    The Focal Adhesion Kinase Inhibitor I, also referenced under CAS 4506-66-5, controls the biological activity of Foca Adhesion Kinase. This small molecule/inhibitor is primarily used for Phosphorylatio More>>

    merck millipore,默克密理博,324877,Focal Adhesion Kinase Inhibitor I - CAS 4506-66-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,324877,Focal Adhesion Kinase Inhibitor I - CAS 4506-66-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₆H₁₀N₄ • 4HCl4506-66-5
    描述
    概述 A cell-permeable tetraamine compound that is identified from a computer-aided molecular docking screening based on Fak Y397 interaction and is shown to inhibit FAK (Cat. No. 324876) autophosphorylation as well as its kinase activity toward paxillin phosphorylation both in cell-free kinase assays (IC50 <1 µM) and in BT474 breast cancer cultures, while exhibiting little activity against Pyk2 (Cat. No. 662067) autophosphorylation or the kinase activity of c-Raf, c-Src, EGFR, VEGFR-3, IGF-1, Met, PDGFR-α, Pyk2, and PI 3-K (p110δ/p85α). Reported to inhibit BT474 proliferation both in cultures in vitro (IC50 ~10 µM) and in mice in vivo (~25% of no treatment controls on day 23; 30 mg/kg via 5 i.p/wk).
    产品目录编号 324877
    品牌系列 Calbiochem®
    同义词 FAK Inhibitor I, 1,2,4,5-Benzenetetraamine, 4HCl, NSC 667249
    参考
    参考 Golubovskaya, V.M., et al. 2008. J. Med. Chem. 51, 7405.
    产品信息
    CAS号 4506-66-5
    形式 Grey solid
    Hill配方 C₆H₁₀N₄ • 4HCl
    化学配方 C₆H₁₀N₄ • 4HCl
    Molar Mass 284.01
    吸湿 Hygroscopic
    结构配方图像
    生物信息
    纯度 ≥95% by elemental analysis
    理化信息
    溶解度 H₂O or DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,324877,Focal Adhesion Kinase Inhibitor I - CAS 4506-66-5 - Calbiochem

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