merck millipore,默克密理愽
  • merck millipore,默克密理博,14-567,Pyk2 Protein, active, 10 µg

  • merck millipore,默克密理博,14-567,Pyk2 Protein, active, 10 µg

    产品名称：Pyk2 Protein, active, 10 µg
    产品型号：14-567
    Active, N-Terminal His6-tagged, recombinant, full-length, human Pyk2. For use in Kinase Assays.

    merck millipore,默克密理博,14-567,Pyk2 Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-567,Pyk2 Protein, active, 10 µg

    描述
    产品目录编号 14-567
    品牌系列 Upstate
    商名
    • Upstate
    描述 Pyk2 Protein, active, 10 µg
    概述 N-Terminal His6-tagged, recombinant, full-length, human Pyk2.
    Alternate Names
    • Related adhesion focal tyrosine kinase (RAFTK), Calcium-dependent tyrosine kinase (CADTK), Proline-rich tyrosine kinase 2 (PRK2), Focal adhesion kinas
    应用
    应用 Active, N-Terminal His6-tagged, recombinant, full-length, human Pyk2. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_173176.1
    • NM_004103.3
    • NM_173174.1
    • NM_173175.1
    Entrez基因汇总 This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
    基因符号
    • PKB
    • PTK2B
    • RAFTK
    • FAK2
    • PYK2
    • FADK2
    • PTK
    • CADTK
    • CAKB
    蛋白靶 Pyk2
    纯化方法 Ni2+/NTA-agarose
    靶子系列 TK
    UniProt编号
    • Q14289
    UniProt汇总 FUNCTION: SwissProt: Q14289 # Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.
    SIZE: 1009 amino acids; 115875 Da
    SUBUNIT: Interacts with Crk-associated substrate (Cas), PTPNS1 and SH2D3C (By similarity). Interacts with nephrocystin, DDEF2, OPHN1L, SKAP2 and TGFB1I1.
    SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Interaction with nephrocystin induces the membrane-association of the kinase.
    TISSUE SPECIFICITY: Most abundant in the brain, with highest levels in amygdala and hippocampus. Low levels in kidney. Also expressed in spleen and lymphocytes.
    PTM: Phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by PKC activation. Recruitment by nephrocystin to cell matrix adhesions initiates Tyr-402 phosphorylation. In monocytes, adherence to substrata is required for tyrosine phosphorylation and kinase activation. Angiotensin II, thapsigargin and L-alpha- lysophosphatidic acid (LPA) also induce autophosphorylation and increase kinase activity (By similarity).
    SIMILARITY: SwissProt: Q14289 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily. & Contains 1 FERM domain. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 10 µg
    包装 Also available in 250 µg size --call for pricing and availability and reference catalog number 14-567M when ordering the 250 µg size.

    merck millipore,默克密理博,14-567,Pyk2 Protein, active, 10 µg

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