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经验配方 CAS号 C₁₅H₁₀O₅ 518-82-1 描述 概述 A cell-permeable, reversible, substrate competitive and potent p56lck tyrosine kinase inhibitor (IC50 = 18.5 µM). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC50 = 15 µM). Also suppresses HER2/neu tyrosine kinase activity in HER2/neu overexpressing breast cancer cells. 产品目录编号 324694 品牌系列 Calbiochem®
同义词 6-Methyl-1,3,8-trihydroxyanthraquinone 参考 参考 Pickhardt, M., et al. 2004. J. Biol. Chem. 280, 3628.
Zhang, L., and Hung. M.C. 1996. Oncogene 12, 571.
Chan, T.C., et al. 1993. Biochem. Biophys. Res. Commun. 193, 1152.
Jayasuriya, H., et al. 1992. J. Nat. Prod. 55, 696.产品信息 CAS号 518-82-1 具有ATP竞争性 N 形式 Orange solid Hill配方 C₁₅H₁₀O₅ 化学配方 C₁₅H₁₀O₅ Molar Mass 270.2 可逆 Y 结构配方图像 生物信息 主靶 p56lck tyrosine kinase 主靶IC50 18.5 µM against p56lck tyrosine kinase 纯度 ≥90% by HPLC 理化信息 细胞可渗透 Y 溶解度 aqueous alkali, DMSO, or EtOH GHS安全信息 RTECS CB7920600 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
无需冷冻 No
特殊指南 Following reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous alkali; reconstitute just prior to use.
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