- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Rb, H, M, Mk, R, B, Ca, Gp, Dr, Sh, Po WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB3102 Replaces 04-1113 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-FADD Antibody 产品信息 格式 Purified 演示 Liquid in PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. (See datasheet for lot specific formulation) 应用 应用 Detect FADD using this Anti-FADD Antibody validated for use in IP & WB. 主要应用 - Western Blotting
应用说明 Immunoblot: 1:250 - 1:1000
Immunoprecipitation: 1:100
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Human FADD synthetic peptide (aa. 125-140) with an additional cysteine residue coupled to KLH. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This immunoaffinity purified antibody detects a 28 kDa protein, corresponding to the expected molecular mass of the FADD on SDS-PAGE, in human chronic myelogenous leukemia (K562), human fibroblast (A431), human cervical epithelial (HeLa), human acute T cell leukemia (Jurkat), human thymus (Hs67), human breast adenocarcinoma (MCF-7), human acute lymphoblastic leukemia (MOLT-4), and monkey kidney (vero) cell lysates as well as in rat brain (very weak) and mouse brain tissue extracts (very weak). 品种反应性 RabbitHumanMouseMonkeyRatBovineCanineGuinea PigDrosophilaSheepPig 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003824.2
Entrez基因汇总 The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. 基因符号 - MGC8528
- FADD
- GIG3
- MORT1
纯化方法 Affinity Purified UniProt编号 - Q13158
UniProt汇总 FUNCTION: SwissProt: Q13158 # Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.
SIZE: 208 amino acids; 23279 Da
SUBUNIT: Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD.
TISSUE SPECIFICITY: Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
DOMAIN:SwissProt: Q13158 Contains a death domain involved in the binding of the corresponding domain within Fas receptor.
PTM: Phosphorylated.
SIMILARITY: Contains 1 death domain. & Contains 1 DED (death effector) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 The undiluted antibody solution is stable for approximately 6 months when stored -20°C. 包装信息 数量 50 µg
上一件merck millipore产品：merck millipore,默克密理博,ABC213,Anti-phospho ULK1 Antibody (Ser777)
下一件merck millipore产品：merck millipore,默克密理博,MAB80126,Anti-Human Metapneumovirus Antibody, clone 136
相关产品
merck millipore,默克密理博,04-1578,Anti-Bruton's tyrosine kinase (Btk) Antibody, clone 10D11
merck millipore,默克密理博,SF-2466,EN2; Human, Cyanine 5 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,524631,Phosphatase Inhibitor Cocktail Set III, Lyophilized
merck millipore,默克密理博,EZHA-52K,Human Amylin ELISA
merck millipore,默克密理博,ABC213,Anti-phospho ULK1 Antibody (Ser777)
merck millipore,默克密理博,MAB80126,Anti-Human Metapneumovirus Antibody, clone 136
merck millipore,默克密理博,324694,Emodin - CAS 518-82-1 - Calbiochem
merck millipore,默克密理博,GF008,Keratinocyte Growth Factor Protein, Recombinant human
merck millipore,默克密理博,03-205,RIPAb+™ hnRNP C1/C2 - RIP Validated Antibody and Primer Set