merck millipore,默克密理愽
  • merck millipore,默克密理博,322338,Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem

  • merck millipore,默克密理博,322338,Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem

    产品名称：Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem
    产品型号：322338
    The Dvl-PDZ Domain Inhibitor II, also referenced under CAS 294891-81-9, controls the biological activity of Dvl-PDZ. This small molecule/inhibitor is primarily used for Protease Inhibitors application More>>

    merck millipore,默克密理博,322338,Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,322338,Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₂H₁₈N₂O₄294891-81-9
    描述
    概述 A cell-permeable amidobenzanilide compound that disrupts Fz-Dvl (frizzled-dishevelled) interaction by targeting the PDZ domain (Kd = 10.6 µM) of Dvl, blocking Wnt3a-induced (10 ng/ml) transcription activity (~50% inhibition at 3 µM in 293 cell SuperTopflash reporter assays) and suppressing the Wnt pathway-dependent growth of prostate cancer PC-3 cells (by 16% in 72 h at ≥50 µM; IC50 = 12.5 µM). Shown to effectively prevent Wnt3A mRNA injection-induced xenopus embryo deformation (effective conc. = 25 µM) and suppress Wnt pathway-mediated apoptosis of the hyaloid vescular endothelial cells in the mouse eyes via vitreous injection (144 fmol/120 nl/eye) in vivo.
    产品目录编号 322338
    品牌系列 Calbiochem®
    同义词 2-((3-(2-Phenylacetyl)amino)benzoyl)amino)benzoic acid, 3289-8625, Wnt Pathway Inhibitor IV
    参考
    参考 Grandy, D., et al. 2009. J. Biol. Chem. 284, 16256.
    产品信息
    CAS号 294891-81-9
    形式 White solid
    Hill配方 C₂₂H₁₈N₂O₄
    化学配方 C₂₂H₁₈N₂O₄
    Molar Mass 374.4
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,322338,Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,MABS731,Anti-PON1, clone EPR2893, Rabbit Monoclonal Antibody


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