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merck millipore,默克密理博,317201,DMBO - Calbiochem
产品名称：DMBO - Calbiochem
产品型号：317201
An oxazine that appears to mimic the pyranosidic moiety of heparin sulfate, and is shown to interact directly with several growth factors and cytokines including VEGF, TNF-α and heparin-binding-EGF in More>>
merck millipore,默克密理博,317201,DMBO - Calbiochem
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重要规格表
经验配方 C₂₂H₂₅F₂NO₂ 描述 概述 An oxazine that appears to mimic the pyranosidic moiety of heparin sulfate, and is shown to interact directly with several growth factors and cytokines including VEGF, TNF-α and heparin-binding-EGF in a surface plasmon resonance assay. At concentrations of 10-80 µM, this compound dose-dependently inhibits the proliferation of VEGF-expressing LM8G7 cells (IC50 = 13 µM), and TNF-α-expressing OVSAHO cells (IC50 = 19 µM). At 195 µM, a 99% reduction in cell growth is observed in HB-EGF-expressing SKOV-3 cultures. This compound inhibits heparanase-mediated degradation of heparin sulfate in LM8G7 cells (IC50 = 65 µM and 104-206 µM, in an enzymatic and a cell based assay, respectively). At 0.5-5 µM, it markedly prevents the migration and invasion of the same culture, in a dose-dependent manner. In addition, it completely suppresses liver metastatic nodules of osteosarcoma mice injected with LM8G7 cells at 0.5 mg/kg without any signs of toxicity in vivo, and demonstrates a synergistic anti-tumor effect when dosed with heparin. 产品目录编号 317201 品牌系列 Calbiochem®
同义词 CCDC-272761 参考 参考 Basappa, et al. 2010. Cancer Lett. 279, 231. 产品信息 形式 White solid Hill配方 C₂₂H₂₅F₂NO₂ 化学配方 C₂₂H₂₅F₂NO₂ Molar Mass 373.4 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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