merck millipore,默克密理博,28745,Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5

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merck millipore,默克密理博,28745,Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem
产品名称：Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem
产品型号：28745
A cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA).

merck millipore,默克密理博,28745,Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem

产品介绍

merck millipore,默克密理博,28745,Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem

重要规格表

经验配方	CAS号
C₁₈H₂₃N₅O₈P · Na	16980-89-5

描述
概述	A cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Causes an increase in the steady state level of parathyroid hormone-related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.
产品目录编号	28745
品牌系列	Calbiochem®
同义词	Dibutyryl-cAMP, Na

参考
参考	Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180. Tsai, C.H., et al. 1995. J. Cell. Physiol. 164, 108. Leszczynski, D., et al. 1994. Am. J. Pathol. 145, 1265. Miller, C., et al. 1994. J. Neurosci. Res. 38, 56. Hinko, A., and Soloff, M.S. 1993. Endocrinology 132, 126. Ikeda, K., et al. 1993. J. Biol. Chem. 268, 1174. Park, E.A., et al. 1993. J. Biol. Chem. 268, 613. Hei, Y-J., et al. 1991. Mol. Pharmacol. 39, 233. Posternak, T., and Weimann, G. 1974. Methods Enzymol. 38, 399.

参考

Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
Tsai, C.H., et al. 1995. J. Cell. Physiol. 164, 108.
Leszczynski, D., et al. 1994. Am. J. Pathol. 145, 1265.
Miller, C., et al. 1994. J. Neurosci. Res. 38, 56.
Hinko, A., and Soloff, M.S. 1993. Endocrinology 132, 126.
Ikeda, K., et al. 1993. J. Biol. Chem. 268, 1174.
Park, E.A., et al. 1993. J. Biol. Chem. 268, 613.
Hei, Y-J., et al. 1991. Mol. Pharmacol. 39, 233.
Posternak, T., and Weimann, G. 1974. Methods Enzymol. 38, 399.

产品信息
CAS号	16980-89-5
具有ATP竞争性	N
形式	White lyophilized solid
Hill配方	C₁₈H₂₃N₅O₈P · Na
化学配方	C₁₈H₂₃N₅O₈P · Na
Molar Mass	491.4
吸湿	Hygroscopic
可逆	N
结构配方图像

生物信息
主靶	PKA
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	H₂O

GHS安全信息
RTECS	ES5055500

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions are stable for up to 3 days at 4°C or for up to 3 months at -20°C. Avoid pH >8.5.