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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-061 品牌系列 Upstate
商名 - Upstate
描述 Anti-MST1/Krs2 Antibody Alternate Names - KAT5
产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Use Anti-MST1/Krs2 Antibody (Rabbit Polyclonal Antibody) validated in IP, WB to detect MST1/Krs2 also known as KAT5. 主要应用 - Western Blotting
生物信息 免疫原品种 GST fusion protein corresponding to residues 276-487 of human MST1/Krs2 宿主 Rabbit 特异性 MST1/Krs2 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006282
Entrez基因汇总 The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. 基因符号 - YSK3
- STK4
- KRS2
- DKFZp686A2068
- MST-1
- MST1
纯化方法 Protein A chromatography UniProt编号 - Q13043
UniProt汇总 FUNCTION: SwissProt: Q13043 # Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Phosphorylates 'Ser-14' of histone H2B during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.
COFACTOR: Magnesium.
SIZE: 487 amino acids; 55630 Da
SUBUNIT: Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation. Interacts with and stabilizes SAV1. Interacts with RASSF1, which leads to enzyme activation. Interacts with FOXO3.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.
TISSUE SPECIFICITY: Ubiquitously expressed.
PTM: Autophosphorylated on serine and threonine residues.
SIMILARITY: SwissProt: Q13043 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 protein kinase domain. & Contains 1 SARAH domain.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from A431 or HeLa cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,219350,Anti-β-Catenin, Dephospho Mouse mAb (8E4)
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