merck millipore,默克密理愽
  • merck millipore,默克密理博,14-537,MKK6/SKK3 (S599D, T603D) Protein, active, 10 µg

  • merck millipore,默克密理博,14-537,MKK6/SKK3 (S599D, T603D) Protein, active, 10 µg

    产品名称：MKK6/SKK3 (S599D, T603D) Protein, active, 10 µg
    产品型号：14-537
    Active, N-terminal MBP tagged, recombinant, human MKK6/SKK3 residues 4-end containing S599D & T603D mutations. For use in Kinase Assays.

    merck millipore,默克密理博,14-537,MKK6/SKK3 (S599D, T603D) Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-537,MKK6/SKK3 (S599D, T603D) Protein, active, 10 µg

    描述
    产品目录编号 14-537
    品牌系列 Upstate
    商名
    • Upstate
    描述 MKK6/SKK3 (S599D, T603D) Protein, active, 10 µg
    概述 N-terminal MBP tagged, recombinant, human MKK6/SKK3 residues 4-end containing S599D and T603D mutations.
    应用
    应用 Active, N-terminal MBP tagged, recombinant, human MKK6/SKK3 residues 4-end containing S599D & T603D mutations. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Human MKK6/SKK3 expressed in E. coli
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_002758.3
    Entrez基因汇总 This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
    基因符号
    • MKK6
    • MAP2K6
    • PRKMK6
    • MEK6
    • SAPKK3
    • MAPKK6
    蛋白靶 MKK6
    纯化方法 Amylose agarose
    靶子系列 STE
    UniProt编号
    • P52564
    UniProt汇总 FUNCTION: SwissProt: P52564 # Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38 exclusively.
    SIZE: 334 amino acids; 37492 Da
    SUBUNIT: Interacts with Yersinia yopJ.
    TISSUE SPECIFICITY: Isoform 2 is only expressed in skeletal muscle. Isoform 1, on the other hand, is found in skeletal muscle, heart, and in lesser extent in liver or pancreas.
    PTM: Weakly autophosphorylated. & Acetylation of Ser-207 and Thr-211 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
    SIMILARITY: SwissProt: P52564 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of p38α/SAPK2a, unactive (14-252).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 10 µg

    merck millipore,默克密理博,14-537,MKK6/SKK3 (S599D, T603D) Protein, active, 10 µg

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