merck millipore,默克密理博,239806,InSolution™ Cyclopamine, V. californicum

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merck millipore,默克密理博,239806,InSolution™ Cyclopamine, V. californicum - Calbiochem
产品名称：InSolution™ Cyclopamine, V. californicum - Calbiochem
产品型号：239806
The InSolution™ Cyclopamine, V. californicum controls the biological activity of Sonic Hedgehog signaling pathway. This small molecule/inhibitor is primarily used for Cancer applications.

merck millipore,默克密理博,239806,InSolution™ Cyclopamine, V. californicum - Calbiochem

产品介绍

merck millipore,默克密理博,239806,InSolution™ Cyclopamine, V. californicum - Calbiochem

重要规格表

经验配方
C₂₇H₄₁NO₂

描述
概述	A cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. The solid form of this compound (Cat. No. 239803) is also available.
产品目录编号	239806
品牌系列	Calbiochem®
同义词	Shh Signaling Antagonist I in EtOH

参考
参考	Berman, D.M., et al. 2003. Nature, 425, 846. Thayer, S.P., et al. 2003. Nature, 425, 851. Watkins, D.N., et al. 2003. Nature 422, 313. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Berman, D.M., et al. 2002. Science 297, 1559. Taipale, J., et al. 2000. Nature 406, 1005. Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036. Cooper, M.K., et al. 1998. Science 280, 1603. Incardona, J.P., et al. 1998. Development 125, 3553.

参考

Berman, D.M., et al. 2003. Nature, 425, 846.
Thayer, S.P., et al. 2003. Nature, 425, 851.
Watkins, D.N., et al. 2003. Nature 422, 313.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Berman, D.M., et al. 2002. Science 297, 1559.
Taipale, J., et al. 2000. Nature 406, 1005.
Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
Cooper, M.K., et al. 1998. Science 280, 1603.
Incardona, J.P., et al. 1998. Development 125, 3553.

产品信息
形式	Liquid
配方	Supplied as a 10 mM (5 mg/1.22 mL) solution of Cyclopamine, V. californicum (Cat. No. 239803) in EtOH.
Hill配方	C₂₇H₄₁NO₂
化学配方	C₂₇H₄₁NO₂
Molar Mass	411.6
吸湿	Hygroscopic
结构配方图像

生物信息
纯度	≥97% by NMR

安全信息
R相	R: 10 Flammable.
S相	S: 16-7 Keep away from sources of ignition - No Smoking. Keep container tightly closed.

储存和货运信息
货运代码	Dry Ice Only
毒性	Flammable
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	≤ -70°C
避光	Protect from light
吸湿	Hygroscopic
避免冻结 / 解冻	Avoid freeze/thaw
无需冷冻	No
特殊指南	Following initial thaw, aliquot and freeze (-70°C).