merck millipore,默克密理博,238590,Cucurbitacin I, Cucumis sativus L. - CAS 117793

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Merck Millipore 默克密理愽

merck millipore,默克密理博,238590,Cucurbitacin I, Cucumis sativus L. - CAS 117793 - Calbiochem

经验配方	CAS号
C₃₀H₄₂O₇	2222-07-3

描述
概述	A cell-permeable and irreversible bitter triterpenoid compound (NCI identifier: NSC 521777) that displays anti-proliferative and antitumor properties both in vitro and in vivo. Acts as a potent and highly selective inhibitor of Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling pathway. It suppresses STAT3 tyrosine phosphorylation in v-Src-transformed NIH 3T3 cells and human lung adenocarcinoma A549 cells (IC₅₀ = 500 nM), resulting in inhibition of STAT3 DNA-binding and STAT3-mediated gene transcription. Shown to inhibit the growth of STAT3-transformed tumors in nude mice. Does not affect oncogenic pathways mediated by Ras, Akt, Erk1/2, or JNK.
产品目录编号	238590
品牌系列	Calbiochem®
同义词	JSI-124, STAT3 Inhibitor XIV

参考
参考	Blaskovich, M.A., et al. 2003. Cancer Res. 63, 1270.

生物信息
主靶	JAK/STAT3
主靶IC₅₀	500 nM suppressing STAT3 tyrosine phosphorylation in v-Src-transformed NIH 3T3 cells and human lung adenocarcinoma A549 cells
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO or EtOH

GHS安全信息
RTECS	RC6200000

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,238590,Cucurbitacin I, Cucumis sativus L. - CAS 117793 - Calbiochem

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