merck millipore,默克密理愽
  • merck millipore,默克密理博,06-500,Anti-p130 Cas Antibody

  • merck millipore,默克密理博,06-500,Anti-p130 Cas Antibody

    产品名称：Anti-p130 Cas Antibody
    产品型号：06-500
    Detect p130 Cas using this Anti-p130 Cas Antibody validated for use in IP, WB & IC.

    merck millipore,默克密理博,06-500,Anti-p130 Cas Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-500,Anti-p130 Cas Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MICC, WBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 06-500
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-p130 Cas Antibody
    概述 has been referred to as anti-Cas3
    产品信息
    格式 Purified
    演示 0.1M Tris-Glycine, pH 7.4, 0.15M NaCl with 0.05% sodium azide
    应用
    应用 Detect p130 Cas using this Anti-p130 Cas Antibody validated for use in IP, WB & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    生物信息
    免疫原品种 GST-fusion protein containing amino acids 691-799 of rat p130 Cas
    宿主 Rabbit
    特异性 p130 Cas
    同种型 IgG
    品种反应性 RatHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_014567
    基因符号
    • p130cas
    • BCAR1
    • CAS
    • p130CAS
    • Crkas
    • P130Cas
    • CRKAS
    纯化方法 Protein A chromatography
    UniProt编号
    • P56945
    UniProt汇总 FUNCTION: SwissProt: P56945 # Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.
    SIZE: 870 amino acids; 93362 Da
    SUBUNIT: Forms complexes in vivo with focal adhesion kinase 1, adapter protein CRKL and LYN kinase. Can heterodimerize with CASL. Interacts with BCAR3, NPHP1, PTK2B and SH2D3C (By similarity). Interacts with activated CSPG4. Interacts with INPPL1/SHIP2.
    SUBCELLULAR LOCATION: Cell junction, focal adhesion (By similarity). Cytoplasm (By similarity). Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation (By similarity).
    TISSUE SPECIFICITY: Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.
    DOMAIN: "SwissProt: P56945 Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2- binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with CASL (By similarity). & A serine-rich region promotes activation of the serum response element (SRE). & The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of focal adhesion kinase 1.
    PTM: Focal adhesion kinase 1 phosphorylates the protein at the YDYVHL motif. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin mediated adhesion of cells to the extracellular matrix.
    SIMILARITY: Belongs to the CAS family. & Contains 1 SH3 domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates of human A431 carcinoma cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 250 µg

    merck millipore,默克密理博,06-500,Anti-p130 Cas Antibody

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