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经验配方 CAS号 Pt(NH₃)₂Cl₂ 15663-27-1 描述 概述 A platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Reported to sensitize glioma cells to TNF-α-induced apoptosis.
Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.产品目录编号 232120 品牌系列 Calbiochem®
同义词 CPDC, DDP, cis-Diaminedichloroplatinum 参考 参考 Hall, M.D., et al. 2014. Cancer Res. In press.
Duan, L., et al. 2001. J. Neurooncol. 52, 23.
Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother. 16, 279.产品信息 CAS号 15663-27-1 具有ATP竞争性 N 形式 Yellow solid Hill配方 Pt(NH₃)₂Cl₂ 化学配方 Pt(NH₃)₂Cl₂ Molar Mass 300.0 可逆 N 结构配方图像 生物信息 主靶 Induces apoptosis in cancer cells 纯度 ≥98% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO, H₂O with 154 mM NaCl, or PBS with 140 mM NaCl GHS安全信息 RTECS TP2450000 安全信息 R相 R: 25-36/37/38-45-42/43
Toxic if swallowed.
Irritating to eyes, respiratory system and skin.
May cause cancer.
May cause sensitization by inhalation and skin contact.S相 S: 22-24-37-45-53
Do not breathe dust.
Avoid contact with skin.
Wear suitable gloves.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid exposure - obtain special instructions before use.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Toxic & Carcinogenic / Teratogenic
有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存 +2°C to +8°C
无需冷冻 No
特殊指南 Unstable in solution; reconstitute just prior to use.
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