merck millipore,默克密理愽
  • merck millipore,默克密理博,14-445M,Casein Kinase 2α Protein, active, 250 µg

  • merck millipore,默克密理博,14-445M,Casein Kinase 2α Protein, active, 250 µg

    产品名称：Casein Kinase 2α Protein, active, 250 µg
    产品型号：14-445M
    Active, 6His-tagged recombinant full length Casein Kinase 2α, human, for use in Kinase Assays.

    merck millipore,默克密理博,14-445M,Casein Kinase 2α Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-445M,Casein Kinase 2α Protein, active, 250 µg

    描述
    产品目录编号 14-445M
    品牌系列 Upstate
    商名
    • Upstate
    描述 Casein Kinase 2α Protein, active, 250 µg
    概述 6His-tagged recombinant fulllength Casein Kinase 2α, human
    应用
    应用 Active, 6His-tagged recombinant full length Casein Kinase 2α, human, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed in Sf21
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因汇总 Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene.
    基因符号
    • CK2 Subunit Alpha
    • CSNK2A1
    • CK2A1
    • CKIIAlpha
    • CKII
    蛋白靶 CK2α
    纯化方法 Ni2+/NTA-agarose
    靶子系列 CMGC
    UniProt编号
    • P68400
    UniProt汇总 Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation.
    产品使用声明
    质量保证 Casein Kinase 2 Substrate Peptide
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -20°C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-445) and in bulk (cat# 14-445-K).

    merck millipore,默克密理博,14-445M,Casein Kinase 2α Protein, active, 250 µg

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