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主要应用 品种 级联部件 EA Human Substrate 描述 产品目录编号 23-045M 品牌系列 Upstate
商名 - Upstate
描述 HIF-1α Protein, 250 µg 长描述 N-terminal c-Myc, GST-tagged, recombinant human HIF-1α amino acids 331-609, expressed by baculovirus in Sf21 insect cells. Purified using glutathione sepharose. Alternate Names - PAS domain-containing protein 8
- Hypoxia-inducible factor 1-alpha
- ARNT-interacting protein
- Basic-helix-loop-helix-PAS protein MOP1
- bHLHe78
背景信息 HIF-1α is the oxygen sensitive subunit of the hypoxia inducible factor HIF-1 which is an essential mediator of the cellular oxygen-signalling pathway. Under hypoxic conditions HIF-1α activates the transcription of over 40 genes, including those that control glucose uptake, metabolism, angiogenesis, erythropoiesis, cell proliferation, and apoptosis. The expression of HIF-1α is commonly increased in a variety of human tumours, and correlates with poor patient prognosis. Under normoxia this protein interacts with the ubiquitin ligase VHL complex, leading to its polyubiquitination and subsequent proteasomal degradation. 应用 应用 Recombinant human HIF-1α amino acids 331-609, N-terminal c-Myc, GST-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays. 主要应用 - Enzyme Assay
生物信息 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. 级联部件 Substrate Entrez基因编号 - NM_001530 (GenBank Number)
纯化方法 Purified using glutathione sepharose. 产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
包装信息 数量 250 µg
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