merck millipore,默克密理愽
  • merck millipore,默克密理博,23-044,VHL Protein Complex, Active, 10 µg

  • merck millipore,默克密理博,23-044,VHL Protein Complex, Active, 10 µg

    产品名称：VHL Protein Complex, Active, 10 µg
    产品型号：23-044
    Active complex of five (5) recombinant human enzymes: VHL amino acids 54-end, full length Elongin C, full length Elongin B, full length Cul2, & full length Rbx1. For use in Enzyme Assays. Functions as More>>

    merck millipore,默克密理博,23-044,VHL Protein Complex, Active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,23-044,VHL Protein Complex, Active, 10 µg

    重要规格表

    主要应用 品种 级联部件
    EAHumanE3
    描述
    产品目录编号 23-044
    品牌系列 Upstate
    商名
    • Upstate
    描述 VHL Protein Complex, Active, 10 µg
    长描述 Complex of N-terminal GST-tagged, recombinant human VHL amino acids 54-end, N-terminal GST tagged, recombinant human Elongin C, untagged, recombinant human Elongin B, N-terminal 6His tagged, recombinant human Cul2 and untagged recombinant human Rbx1 co-expressed by baculovirus in Sf21 insect cells. Purified using glutathione sepharose.
    Alternate Names
    • CBC<sup>VHL</sup>
    • VCB-Cul2 complex
    • ECV complex
    背景信息 The VHL complex is a multi-subunit ubiquitin ligase composed of VHL, Elongin B, Elongin C, Cul2 and Rbx1. The VHL protein serves as the substrate recognition component and is linked by Elongin C to a heterodimeric Cul2/Rbx1 module that functions as a potent activator of the ubiquitination of target proteins by an E2 conjugating enzyme. Elongin B interacts with the complex through Elongin C and appears to stabilize the binding of Elongin C to VHL. The primary function of the VHL complex is to regulate HIF (hypoxia inducible factor) activity by targeting the hydroxylated HIF-1α subunit for ubiquitination and rapid proteasomal degradation under normoxic conditions. It therefore plays an important role in the regulation of hypoxia-inducible genes such as the vascular endothelial growth factor (VEGF) and glucose transport-1 (Glut-1). Mutations in VHL are associated with the inherited von Hippel-Lindau (VHL) cancer syndrome and numerous forms of renal cell carcinoma.
    应用
    应用 Active complex of five (5) recombinant human enzymes: VHL amino acids 54-end, full length Elongin C, full length Elongin B, full length Cul2, & full length Rbx1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
    主要应用
    • Enzyme Assay
    生物信息
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    级联部件 E3
    Entrez基因编号
    • NM_014248 (Rbx1) (GenBank Number)
    • NM_000551 (VHL) (GenBank Number)
    • NM_005648 (Elongin C) (GenBank Number)
    • NM_007108 (Elongin B) (GenBank Number)
    • NM_003591 (Cul2) (GenBank Number)
    纯化方法 Purified using glutathione sepharose.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 10 µg

    merck millipore,默克密理博,23-044,VHL Protein Complex, Active, 10 µg

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