merck millipore,默克密理愽
  • merck millipore,默克密理博,219494,Cdk/CKI Inhibitor, (R)-DRF053 - CAS 1186647-87-9 - Calbiochem

  • merck millipore,默克密理博,219494,Cdk/CKI Inhibitor, (R)-DRF053 - CAS 1186647-87-9 - Calbiochem

    产品名称：Cdk/CKI Inhibitor, (R)-DRF053 - CAS 1186647-87-9 - Calbiochem
    产品型号：219494
    The Cdk/CKI Inhibitor, (R)-DRF053, also referenced under CAS 1186647-87-9, controls the biological activity of Cdk/CKI. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphor More>>

    merck millipore,默克密理博,219494,Cdk/CKI Inhibitor, (R)-DRF053 - CAS 1186647-87-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,219494,Cdk/CKI Inhibitor, (R)-DRF053 - CAS 1186647-87-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₃H₂₇N₇O • H₂O1186647-87-9
    描述
    概述 A cell-permeable ATP-binding pocket-targeting (R)-Roscovitine (Cat. Nos. 550360 & 550364) derivative that is more potent than Roscovitine in inhibiting CDK1,CDK5, and CK1 activity (IC50 = 220,80,14 vs. 350, 200, 2300 nM, respectively), while maintaining selectivity against GSK-3α/β (IC50 = 4.1 µM). The CDK/CK1 dual-specificity nature of (R)-DRF053 most likely accounts for its superior activity to that of (R)-Roscovitine against β40 production from APP-expressing N2A cells (90% vs. 50% inhibition wtih 100 µM respective compound).
    产品目录编号 219494
    品牌系列 Calbiochem®
    同义词 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(3-(2-pyridyl)phenylamino)-9-isopropylpurine, hydrate
    参考
    参考 Oumata, N., et al. J. Med. Chem. 51, 5229.
    Bettayeb, K., et al. 2008. Oncogene 27, 5797.
    产品信息
    CAS号 1186647-87-9
    形式 Pale yellow solid
    Hill配方 C₂₃H₂₇N₇O • H₂O
    化学配方 C₂₃H₂₇N₇O • H₂O
    Molar Mass 435.5
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,219494,Cdk/CKI Inhibitor, (R)-DRF053 - CAS 1186647-87-9 - Calbiochem

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