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描述 概述 Cathepsin K is a member of the papain superfamily of cysteine proteinases and plays an important role in osteoclast-mediated bone resorption and collagen degradation. It is primarily expressed by osteoclasts and recent studies also suggest its expression in fibroblasts. Irregularities in cathepsin K activity, either too high or too low, contribute to osteopenic disorders such as osteoporosis and pycnodysostosis. This recombinant enzyme contains a C-terminal His•Tag® sequence. Note: 1 mU = 1 milliunit. 产品目录编号 219461 品牌系列 Calbiochem®
参考 参考 Delaisse, J.M., et al. 2003. Microsc. Res. Tech. 61, 504.
Dodds, R.A. 2003. Cell Biochem. Funct. 21, 231.
Everts, V., et al. 2003. Calcif. Tissue Int. 73, 380.
Hou, W.S., et al. 2003. Biol. Chem. 384, 891.产品信息 CAS号 94716-09-3 EC号 3.4.22.38 形式 Liquid 配方 In 50 mM NaOAC, pH 5.5. The activation was stopped by addition of 10 mM MMTS, which can be removed under reducing conditions. Molar Mass 27000 生物信息 纯度 ≥95% by SDS-PAGE 特异活性 ≥900 mU/mg protein 浓缩标签 Please refer to vial label for lot-specific concentration
储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C).
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