merck millipore,默克密理愽
  • merck millipore,默克密理博,218719,Casein Kinase I Inhibitor III, PF-4800567 - Calbiochem

  • merck millipore,默克密理博,218719,Casein Kinase I Inhibitor III, PF-4800567 - Calbiochem

    产品名称：Casein Kinase I Inhibitor III, PF-4800567 - Calbiochem
    产品型号：218719
    The Casein Kinase I Inhibitor III, PF-4800567 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,218719,Casein Kinase I Inhibitor III, PF-4800567 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,218719,Casein Kinase I Inhibitor III, PF-4800567 - Calbiochem

    重要规格表

    经验配方
    C₁₇H₁₈ClN₅O₂
    描述
    概述 A cell-permeable pyrazolopyrimidinylamino compound that acts as a potent, ATP-competitive and reversible inhibitor of CKIε with ~22-fold greater potency over CKIδ (IC50 = 32 and 711 nM, respectively) and displays excellent selectivity among 50-kinases, with the only exception of EGFR (69% inhibition at 1 µM). Shown to preferentially block PER3 (PERIOD3) nuclear translocation in COS7-GFP-PER3-CKIε cells over CKIδ-transfected cells (IC50 = 0.13 and 2.65 µM, respectively), and PER2 degradation in COS7-GFP-PER2-CKIε cells. Unlike Casein Kinase I Inhibitor II, PF-670462 (Cat. No. 218716), PF-4800567 exerts only marginal effect on circadian clock under similar conditions.
    产品目录编号 218719
    品牌系列 Calbiochem®
    同义词 3-(3-Chlorophenoxymethyl)-1-(tetrahydropyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine, HCl, CKI Inhibitor III, PF-4800567
    参考
    参考 Meng, Q.J., et al. 2010. Proc. Natl. Acad. Sci. USA 24, 15240.
    Etchegaray, J.P., et al. 2010. PLoS One 5, e10303.
    Walton, K.M., et al. 2009. J. Pharmacol. Exp. Ther. 330, 430.
    Badura, L., et al. 2007. J. Pharmacol. Exp. Ther. 322, 730.
    产品信息
    形式 Beige solid
    Hill配方 C₁₇H₁₈ClN₅O₂
    化学配方 C₁₇H₁₈ClN₅O₂
    Molar Mass 359.8
    结构配方图像
    生物信息
    纯度 ≥99% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,218719,Casein Kinase I Inhibitor III, PF-4800567 - Calbiochem

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