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merck millipore,默克密理博,SF-799,TIMP3; Human, Cyanine 5, RNA Detection Probe,SmartFlare
产品名称：TIMP3; Human, Cyanine 5, RNA Detection Probe, SmartFlare
产品型号：SF-799
Use SmartFlare RNA Detection probes to measure gene expression in live cells. With an overnight incubation of SmartFlare TIMP3, Human, Cyanine 5, you can detect TIMP3 RNA levels within your cells.
merck millipore,默克密理博,SF-799,TIMP3; Human, Cyanine 5, RNA Detection Probe,SmartFlare
- 产品介绍
重要规格表
Entrez Gene Number Species Reactivity NM_000362.4 H 描述 产品目录编号 SF-799 商名 - SmartFlare
描述 TIMP3; Human, Cyanine 5, RNA Detection Probe | SmartFlare Alternate Names - K222TA2
- SFD
- K222
背景信息 With SmartFlare™ RNA Detection probes, you can detect RNA in LIVE CELLS with ease. With just an overnight incubation of TIMP3; Human, Cyanine 5, RNA Detection Probe you can detect the presence of TIMP3 within your cells.
Matrix metalloproteinases (MMPs) are a family of enzymes that are responsible for the degradation of extracellular matrix components such as collagen, laminin, and proteoglycans. In addition to sequence homology, all MMPs share the following characteristics: the catalytic mechanism is dependent upon a zinc ion at the active center, they cleave one or more extracellular matrix components, they are secreted as zymogens which are activated by removal of an ~10 kDa segment from the N-terminus, and their activity is regulated by endogenous inhibitors. These enzymes are involved in normal physiological processes such as embryogenesis and tissue remodeling and may play an important role in arthritis, periodontitis, and metastasis.
The activation and activity of MMPs are regulated by a family of endogenous inhibitors, tissue inhibitiors of metalloproteinase (TIMP). TIMP-3 is a 27 kDa glycoprotein (24 kDa unglycosylated) extracellular-matrix associated protein that is expressed by a variety of cell types. It forms a non-covalent, stoichiometric complex with both latent and active MMPs. TIMP-3 inhibits activation of progelatinase A by MT2-MMP. TIMPs are capable of altering the metastatic potential of cancer cells and have been shown to inhibit invasion and metastasis in animal models as well as to be subject to differential expresssion in other disease states. Expression of TIMP-3 is quite marked in the eye and it has recently been shown that Sorsby's fundus dystrophy, a dominant inherited form of blindness is caused by mutation in the gene encoding TIMP-3.产品信息 格式 Cyanine 5 演示 Lyophilized 应用 应用 Use SmartFlare RNA Detection probes to measure gene expression in live cells. With an overnight incubation of SmartFlare TIMP3, Human, Cyanine 5, you can detect TIMP3 RNA levels within your cells. 主要应用 - RNA Detection
生物信息 品种反应性 Human Entrez基因编号 - NM_000362.4
基因符号 - TIMP3
产品使用声明 质量保证 SmartFlare Probes have been tested in a buffer system to detect the release of the fluorophore in the presence of a complimentary base pair sequence for each lot to confirm target specificity. SmartFlare Probes have also been tested in a cell model system and demonstrated increased fluorescence in cells expressing the target compared to a negative SmartFlare Scramble Control. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at 2–8°C in lyophilized format ONLY. Room temperature is required for reconstituted product. 包装信息 数量 250 reactions
上一件merck millipore产品：merck millipore,默克密理博,07-2129,Anti-phospho-Abi-1 (Ser225) Antibody
下一件merck millipore产品：merck millipore,默克密理博,SF-1277,VPS35; Human, Cyanine 5 RNA Detection Probe,SmartFlare
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