merck millipore,默克密理愽
  • merck millipore,默克密理博,217695,Cdk1 Inhibitor - CAS 220749-41-7 - Calbiochem

  • merck millipore,默克密理博,217695,Cdk1 Inhibitor - CAS 220749-41-7 - Calbiochem

    产品名称：Cdk1 Inhibitor - CAS 220749-41-7 - Calbiochem
    产品型号：217695
    The Cdk1 Inhibitor, also referenced under CAS 220749-41-7, controls the biological activity of Cdk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation application More>>

    merck millipore,默克密理博,217695,Cdk1 Inhibitor - CAS 220749-41-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,217695,Cdk1 Inhibitor - CAS 220749-41-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₇H₁₁ClN₂O220749-41-7
    描述
    概述 A cell-permeable indolylmethylene-2-indolinone derivative that exhibits potent anti-proliferative properties (IC50 = 2 µM HeLa cells). Acts as a selective, reversible and ATP-competitive inhibitor of Cdk1/cyclin B (IC50 = 5.8 µM). Also inhibits Cdk5 with a IC50 = 25 µM. Binds to the ATP pocket on the Cdk1 active site. Does not affect the activity of GSK-3β even at 100 µM concentrations.
    产品目录编号 217695
    品牌系列 Calbiochem®
    同义词 3-(2-Chloro-3-indolylmethylene)-1,3-dihydroindol-2-one
    参考
    参考 Andreani, A., et al. 2000. Anticancer Drug Des. 15, 447.
    Andreani, A., et al. 1996. Anticancer Res. 16, 3585.
    产品信息
    CAS号 220749-41-7
    具有ATP竞争性 Y
    形式 Orange solid
    Hill配方 C₁₇H₁₁ClN₂O
    化学配方 C₁₇H₁₁ClN₂O
    Molar Mass 294.7
    可逆 Y
    结构配方图像
    生物信息
    主靶 Cdk1
    主靶IC50 2 µM for anti-proliferative properties in HeLa cells; 5.8 µM against Cdk1/cyclin B
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,217695,Cdk1 Inhibitor - CAS 220749-41-7 - Calbiochem

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