merck millipore,默克密理博,171264,InSolution™ AMPK Inhibitor, Compound C•2HCl - CAS 866405-64-3

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Merck Millipore 默克密理愽

merck millipore,默克密理博,171264,InSolution™ AMPK Inhibitor, Compound C•2HCl - CAS 866405-64-3 - Calbiochem

经验配方	CAS号
C₂₄H₂₅N₅O	866405-64-3

描述
概述	A cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; K_i = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No. 123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice. The solid form of this compound (Cat. No. 171260) is also available.
产品目录编号	171264
品牌系列	Calbiochem®
同义词	6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H₂O, Compound C, 2HCl, H₂O, AMPK Inhibitor I

参考
参考	Yu, P.B., et al. 2008. Nat. Chem. Biol 4, 33. Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970. Lee, M., et al. 2003. J. Biol. Chem. 278, 39653. Inoki, K., et al. 2003. Cell 115, 577. Fryer, L.G., 2002. FEBS Lett. 531, 189. Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.

产品信息
CAS号	866405-64-3
形式	Liquid
配方	A 10 mM (2 mg/408 µl) solution of AMPK Inhibitor, Compound C, 2HCl, (Cat. No. 171260) in H₂O.
Hill配方	C₂₄H₂₅N₅O
化学配方	C₂₄H₂₅N₅O
Molar Mass	399.5
结构配方图像

生物信息
纯度	≥98% by HPLC

储存和货运信息
货运代码	Dry Ice Only
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following intial thaw, aliquot and freeze (-20°C).

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,171264,InSolution™ AMPK Inhibitor, Compound C•2HCl - CAS 866405-64-3 - Calbiochem

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