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merck millipore,默克密理博,21-170,TOPflash (TCF Reporter Plasmid)
产品名称：TOPflash (TCF Reporter Plasmid)
产品型号：21-170
Transfection grade T-cell factor reporter plasmid containing 2 sets (withthe second set in the reverse orientation) of 3 copies of the TCF binding site (wild type) upstream of the Thymidine Kina More>>
merck millipore,默克密理博,21-170,TOPflash (TCF Reporter Plasmid)
- 产品介绍
描述 产品目录编号 21-170 品牌系列 Upstate
商名 - Upstate
描述 TOPflash (TCF Reporter Plasmid) 应用 应用 Transfection grade T-cell factor reporter plasmid containing 2 sets (with
the second set in the reverse orientation) of 3 copies of the TCF binding site (wild type) upstream of the Thymidine Kinase minimal promoter and
Luciferase open reading frame.主要应用 - Transfection
生物信息 Entrez基因编号 - NM_000545.4
Entrez基因汇总 This gene encodes transcription factor 4, a basic helix-turn-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is expressed predominantly in pre-B-cells, although it is found in other tissues as well. Multiple alternatively spliced transcript variants that encode different proteins have been described. 基因符号 - HNF1a
- TCF1
- MODY3
- HNF1
- HNF-1A
- TCF-1
- HNF1A
- LFB1
UniProt编号 - P15884
- P20823
- P15923
UniProt汇总 FUNCTION: SwissProt: P20823 # Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
SIZE: 631 amino acids; 67356 Da
SUBUNIT: Binds DNA as a dimer.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Liver.
DISEASE: SwissProt: P20823 # Defects in HNF1A may predispose to hepatic adenomas [MIM:142330]. Hepatic adenomas are benign tumors at risk of malignant transformation. Bi-allelic inactivation of HNF1A, whether sporadic or associated with MODY3, may be an early step in the developmant of some hepatocellular carcinomas. & Defects in HNF1A are the cause of maturity onset diabetes of the young type 3 (MODY3) [MIM:600496]; also symbolized MODY-3. MODY [MIM:606391] is a form of diabetes characterized by an autosomal dominant mode of inheritance, age of onset of 25 years or younger and a primary defect in insulin secretion. The clinical phenotype of MODY3 is characterized by severe insulin secretory defects, and by major hyperglycemia associated with microvascular complications. & Defects in HNF1A are a cause of susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100].
SIMILARITY: SwissProt: P20823 ## Belongs to the HNF1 homeobox family. & Contains 1 homeobox DNA-binding domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
包装信息 数量 5 µg
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下一件merck millipore产品：merck millipore,默克密理博,HTS037M,ChemiSCREEN™ Membrane Preparation Recombinant Human PAR2 Protease-Activated Receptor
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