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品种反应性 主要应用 宿主 格式 抗体类型 Ch, H, R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABD24 描述 Anti-Dermo-1 Antibody Alternate Names - Dermo-1
- Twist-related protein 2
- Class A basic helix-loop-helix protein 39
- bHLHa39
- Dermis-expressed protein 1
背景信息 Dermo-1, also known as Twist-related protein 2, is a basic helix-loop-helix transcription factor that has been shown to be a negative regulator for gene transcription and apoptosis. Basic helix-loop-helix transcription factors are implicated in cell lineage determination and differentiation. Dermo-1 shares extensive homology with another basic helix-loop-helix transcription factor, Twist. Studies suggest that Dermo-1 may inhibit osteoblast maturation during osteoblast development and maintain cells in preosteoblast phenotype. 产品信息 格式 Affinity Purified 控制 - Rat liver tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Dermo-1 Antibody is an antibody against Dermo-1 for use in WB, IH(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Dermo-1 in rat liver tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Dermo-1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 ChickenHumanRat Species Reactivity Note Demonstrated to react with Human and Rat. Predicted to react with Mouse and Chicken based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_476527
Entrez基因汇总 Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Twist. It is thought that during osteoblast development this protein may inhibit osteoblast maturation and maintain cells in a ossteoblast phenotype. [provided by RefSeq, Jul 2008]. 基因符号 - DERMO1
- TWIST2
- BHLHA39
纯化方法 Affinity purified UniProt编号 - Q8WVJ9
UniProt汇总 FUNCTION: Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. Ref.1 UniProtKB Q9D030
SUBUNIT STRUCTURE: Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3/E12. Also interacts with MEF2C (By similarity). UniProtKB Q9D030
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Mainly nuclear during embryonic development. Cytoplasmic in adult tissues.
TISSUE SPECIFICITY: In the embryo, highly expressed in chondrogenic cells. In embryonic skin, expressed in the undifferentiated mesenchymal layer beneath the epidermis which later develops into the dermis. Expressed in early myeloid cells but not in lymphoid cells in the liver. Expression also detected in the secretory ependymal epithelium of the choroid plexus primordium. In the adult, expressed in secreting glandular tissues and tubules.
INVOLVEMENT IN DISEASE: Defects in TWIST2 are the cause of Setleis syndrome (SETLEISS) [MIM:227260]. A focal facial dermal dysplasia characterized by distinctive bitemporal scar-like depressions resembling forceps marks, and additional facial features, including a coarse and leonine appearance, absent eyelashes on both lids or multiple rows on the upper lids, absent Meibomian glands, slanted eyebrows, chin clefting, and hypo- or hyperpigmentation of the skin. Histologically, the bitemporal lesion is an ectodermal dysplasia with near absence of subcutaneous fat, suggesting insufficient migration of neural crest cells into the frontonasal process and the first branchial arch.
SEQUENCE SIMILARITIES: Contains 1 basic helix-loop-helix (bHLH) domain.产品使用声明 质量保证 Evaluated by Western Blot in rat liver tissue lysate.
Western Blot Analysis: 0.05 µg/mL of this antibody detected Dermo-1 on 10 µg of rat liver tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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