merck millipore,默克密理博,208851,Calyculin A, Discodermia calyx - CAS 101932-71-2

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merck millipore,默克密理博,208851,Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem
产品名称：Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem
产品型号：208851
A cell-permeable inhibitor of protein phosphatase 2A (PP2A; IC₅₀ = 0.5-1 nM) and protein phosphatase 1 (PP1; IC₅₀ = 2 nM).

merck millipore,默克密理博,208851,Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem

产品介绍

merck millipore,默克密理博,208851,Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem

重要规格表

经验配方	CAS号
C₅₀H₈₁N₄O₁₅P	101932-71-2

描述
概述	A cell-permeable inhibitor of protein phosphatase 2A (PP2A; IC₅₀ = 0.5-1 nM) and protein phosphatase 1 (PP1; IC₅₀ = 2 nM). A non-phorbol ester type tumor promoter that induces oxidative DNA damage. Selectively increases the efficacy of AMPA receptor-mediated synaptic transmission at excitatory synapses. Also known to prevent γ-radiation induced apoptosis in Burkitt’s lymphoma cell line BM13674. Also available as a 100 µM solution in DMSO (Cat. No. 508226).
产品目录编号	208851
品牌系列	Calbiochem®

参考
参考	Murakami, N., et al. 1994. Neurosci. Lett. 176, 181. Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803. Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083. Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47. Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950. Carl, A., et al. 1991. Am. J. Physiol. 261, C387. Suganuma, M., et al. 1990. Cancer Res. 50, 3521. Cohen, P. 1989. Annu. Rev. Biochem. 58, 453. Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435. Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871. Kato, Y., et al. 1988. J. Org. Chem. 53, 3930. Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.

参考

Murakami, N., et al. 1994. Neurosci. Lett. 176, 181.
Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803.
Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083.
Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47.
Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
Carl, A., et al. 1991. Am. J. Physiol. 261, C387.
Suganuma, M., et al. 1990. Cancer Res. 50, 3521.
Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435.
Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871.
Kato, Y., et al. 1988. J. Org. Chem. 53, 3930.
Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.

产品信息
CAS号	101932-71-2
具有ATP竞争性	N
形式	Clear film to white crystalline powder
Hill配方	C₅₀H₈₁N₄O₁₅P
化学配方	C₅₀H₈₁N₄O₁₅P
Molar Mass	1009.2
吸湿	Hygroscopic
可逆	N
结构配方图像

生物信息
主靶	PP2A
主靶IC₅₀	0.5-1 nM and 2 nM against protein phosphatase 2A (PP2A) and protein phosphatase 1 (PP1)
纯度	≥98% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO or EtOH

安全信息
R相	R: 23/24/25-38 Toxic by inhalation, in contact with skin and if swallowed. Irritating to skin.
S相	S: 26-36/37/39-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Toxic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	-20°C
避光	Protect from light
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 12 months at 4°C.