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merck millipore,默克密理博,189299,ATR/CDK Inhibitor, NU6027 - CAS 220036-08-8 - Calbiochem
产品名称：ATR/CDK Inhibitor, NU6027 - CAS 220036-08-8 - Calbiochem
产品型号：189299
The ATR/CDK Inhibitor, NU6027, also referenced under CAS 220036-08-8, controls the biological activity of ATR/CDK. This small molecule/inhibitor is primarily used for Cancer applications.
merck millipore,默克密理博,189299,ATR/CDK Inhibitor, NU6027 - CAS 220036-08-8 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₁H₁₇N₅O₂ 220036-08-8 描述 概述 A cell-permeable, pyrimidine derivative that acts as an ATP-competitive CDK Inhibitor (Ki = 2.5 µM for CDK1, and Ki = 1.3 µM for CDK2), and demonstrates cytostatic properties among a panel of 57 cancer cell lines. Also inhibits ATR kinase (IC50 = 6.7 µM in MCF7 cells), but does not interfere with irradiation-induced autophosphorylation of DNA-PK or ATM. Potentiates a range of DNA-damaging cytotoxic drugs such as hydroxyurea (1.8-fold) and cisplatin (1.4-fold) at 10 µM, but not the anti-mitotic paclitaxel. Attenuates G2/M arrest following DNA damage and inhibits RAD51 focus formation. Shown to be synthetically lethal when DNA single-strand break repair is impaired in PARP-inhibited cells. 产品目录编号 189299 品牌系列 Calbiochem®
同义词 ATR Inhibitor, NU6027, 2,6-diamino-4-cyclohexyl-methyloxy-5-nitroso-pyrimidine, CDK2 Inhibitor, NU6027 参考 参考 Peasland, A., et al. 2011., Br J Cancer. 105, 372.
Arris, C.E, et al. 2000., J Med Chem. 43, 2797.产品信息 CAS号 220036-08-8 形式 Reddish-purple powder Hill配方 C₁₁H₁₇N₅O₂ 化学配方 C₁₁H₁₇N₅O₂ Molar Mass 251.28 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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