merck millipore,默克密理愽
  • merck millipore,默克密理博,204885,Complement C3, Human

  • merck millipore,默克密理博,204885,Complement C3, Human

    产品名称：Complement C3, Human
    产品型号：204885


    merck millipore,默克密理博,204885,Complement C3, Human

  • 产品介绍
  • merck millipore,默克密理博,204885,Complement C3, Human

    描述
    概述 Native, human C3 complement component. Glycoprotein composed of two non-identical disulfide-bonded subunits with M.W. of 115 kDa (α) and 75 kDa (β). Present in normal human serum at 1.25 mg/ml. Classical and alternative activation pathways of complement converge at C3 step. Activation via either pathway can result in assembly of C3-cleaving enzymes (C3 convertases) on target surfaces. Both C3 convertases cleave the C3 α-chain at peptide bond 77 resulting in production of C3a (M.W. 9083) and C3b fragments (M.W. 180,000). Released C3a peptide is one of the three complement anaphylatoxins. The nascent C3b fragment can form a covalent ester bond with target surface. This covalent attachment of C3b to target acceptors is required for continuation of complement activation.
    产品目录编号 204885
    品牌系列 Calbiochem®
    参考
    参考 Lambris, J.D. and Muller-Eberhard, H.J. 1986. Mol. Immunol. 23, 1237.
    Tack, B.F., et al. 1980. Methods Enzymol. 80, 64.
    产品信息
    CAS号 80295-41-6
    形式 Liquid
    配方 In PBS, pH 7.2.
    Molar Mass 190000
    生物信息
    生物活性 >3,000 C₃H₅0 units/mg; ≥60% of the C3 activity in normal human serum on a mg/mg basis.
    纯度 ≥95% by SDS-PAGE
    来源 Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
    理化信息
    污染物 IgG, IgA, IgM, C4, functionally active C5, albumin or ceruloplasmin: ≤trace amounts
    储存和货运信息
    货运代码 Dry Ice Only
    毒性 Standard Handling
    储存 ≤ -70°C
    避免冻结 / 解冻 Avoid freeze/thaw
    无需冷冻 No
    特殊指南 Following initial thaw, aliquot and freeze (-70°C).

    merck millipore,默克密理博,204885,Complement C3, Human

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下一件merck millipore产品：merck millipore,默克密理博,QIA88,ProteoExtract Cytosol/Mitochondria Fractionation Kit


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