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merck millipore,默克密理博,196806,Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem
产品名称：Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem
产品型号：196806
A MAC (Mitochondrial Apoptosis-induced Channel) inhibitor iMAC1 tructural analog that is reported to be less potent than iMAC1 in blocking Bid-induced cytochrome c release in cell-free mitochon More>>
merck millipore,默克密理博,196806,Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem
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重要规格表
经验配方 CAS号 C₁₉H₂₀Br₂FN₃ •2HCl 335166-00-2 描述 概述 A MAC (Mitochondrial Apoptosis-induced Channel) inhibitor iMAC1 (Cat. No. 196805) structural analog that is reported to be less potent than iMAC1 in blocking Bid-induced cytochrome c release in cell-free mitochondria preparations (40% vs. 77% inhibition with 5 µM respective inhibitor), but more effective than iMAC1 in inhibiting STS- (Cat. No. 569396 & 569397) induced cytochrome c release in intact FL5.12 cells (Complete vs ~35% inhibition with 5 µM respective inhibitor), presumably due to an enhanced permeability. iMAC2 is also shown to be a superior blocker of MAC-mediated current flow in reconstituted mitochondrial outer membrane patches from apoptotic FL5.12 cells (IC50 = 28 vs 300 nM in the case of iMAC2 and iMAC1, respectively) and protect FL5.12 from STS-induced apoptosis (IC50 = 2.5 µM). 产品目录编号 196806 品牌系列 Calbiochem®
同义词 (±)-3,6-Dibromo-9-(2-fluoro-3-piperazin-1-yl-propyl)-carbazole, 2HCl, MAC Inhibitor II 参考 参考 Peixoto, P.M., et al. 2009. Biochem. J. 423, 381.
Bombrun, A., et al. 2003. J. Med. Chem. 46, 4365.产品信息 CAS号 335166-00-2 形式 Off-white solid Hill配方 C₁₉H₂₀Br₂FN₃ •2HCl 化学配方 C₁₉H₂₀Br₂FN₃ •2HCl Molar Mass 542.1 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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