merck millipore,默克密理愽

  • 产品介绍

  • 重要规格表

    Uni Prot编号
    P62140, P62136
    描述
    产品目录编号 19-161
    品牌系列 Upstate
    商名
    • Upstate
    描述 PHI-1
    产品信息
    演示 PBS
    应用
    主要应用
    • Kinase Assay
    应用说明 Highly specific inhibitor of type-1 Ser/Thr phosphatase (PP1).
    生物信息
    Entrez基因编号
    • NM_206873.1
    • NM_001008709.1
    • NM_002708.3
    Entrez基因汇总 The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.
    基因符号
    • PPP1A
    • PPP1CA
    • PP-1A
    • MGC15877
    • MGC1674
    UniProt编号
    • P62140
    • P62136
    UniProt汇总 FUNCTION: SwissProt: P62140 # Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity.
    COFACTOR: Binds 1 iron ion per subunit (By similarity). & Binds 1 manganese ion per subunit (By similarity).
    SIZE: 327 amino acids; 37187 Da
    SUBUNIT: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A and PPP1R12B mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen (By similarity). Interacts with PPP1R7.
    SUBCELLULAR LOCATION: Cytoplasm (By similarity).
    SIMILARITY: SwissProt: P62140 ## Belongs to the PPP phosphatase family. PP-1 subfamily.
    产品使用声明
    质量保证 Routinely evaluated by inhibition of dephosphorylation of phosphorylase by PP-1
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 50 µg


上一件merck millipore产品：merck millipore,默克密理博,69671,Thrombin, Restriction Grade
下一件merck millipore产品：merck millipore,默克密理博,FCMAB132F,Milli-Mark™ Anti-TRA-1-81 Antibody, clone TRA-1-81, FITC Conjugate


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