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merck millipore,默克密理博,19-134,p38/SAPK2 Inhibitor (SB 202190)
产品名称：p38/SAPK2 Inhibitor (SB 202190)
产品型号：19-134
The p38/SAPK2 Inhibitor (SB 202190) controls the biological activity of p38/SAPK2. This small molecule/inhibitor is primarily used for Biochemicals applications.
merck millipore,默克密理博,19-134,p38/SAPK2 Inhibitor (SB 202190)
- 产品介绍
重要规格表
Uni Prot编号 Q15759 描述 产品目录编号 19-134 品牌系列 Upstate
商名 - Upstate
描述 p38/SAPK2 Inhibitor (SB 202190) 产品信息 演示 C20H14FN3O 应用 应用 The p38/SAPK2 Inhibitor (SB 202190) controls the biological activity of p38/SAPK2. This small molecule/inhibitor is primarily used for Biochemicals applications. 主要应用 - Kinase Assay
应用说明 Potent inhibitor of p38 alpha/SAPK2a and p38 beta/SAPK2b kinases. 生物信息 Entrez基因编号 - NM_002751.5
Entrez基因汇总 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. 基因符号 - P38BETA2
- MAPK11
- p38-2
- p38b
- P38B
- p38Beta
- p38beta2
- SAPK2B
- SAPK2
- PRKM11
蛋白靶 p38/SAPK2 靶子系列 CMGC UniProt编号 - Q15759
UniProt汇总 FUNCTION: SwissProt: Q15759 # Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2.
COFACTOR: Magnesium (By similarity).
SIZE: 364 amino acids; 41357 Da
TISSUE SPECIFICITY: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
DOMAIN:SwissProt: Q15759 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
PTM: Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme (Probable).
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 Routinely evaluated in a kinase assay as an inhibitor. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 3 years at -20°C 包装信息 数量 1 mg
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