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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-646 Replaces 04-448 品牌系列 Upstate
商名 - Upstate
描述 Anti-phospho-HSP27 (Ser82) Antibody 产品信息 格式 Purified 演示 70% (0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide) and 30% glycerol 应用 应用 This Anti-phospho-HSP27 (Ser82) Antibody is validated for use in WB for the detection of phospho-HSP27 (Ser82). 主要应用 - Western Blotting
生物信息 免疫原品种 Peptide corresponding to amino acids 79-89 of human heat shock protein 27 (HSP27). 宿主 Rabbit 特异性 HSP27 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody 基因符号 - HSP28
- HSPB1
- Hs.76067
- HSP27
- CMT2F
- DKFZp586P1322
- SRP27
- HspB1
- HS.76067
- HMN2B
- Hsp25
修改 - Phosphorylation
纯化方法 Protein A purfied UniProt编号 - P04792
UniProt汇总 FUNCTION: SwissProt: P04792 # Involved in stress resistance and actin organization.
SIZE: 205 amino acids; 22783 Da SUBUNIT: Interacts with TGFB1I1 (By similarity). Associates with alpha- and beta-tubulin and microtubules. Interacts with HSPB8 and HSPBAP1.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock.
PTM: Phosphorylated in MCF-7 cells on exposure to protein kinase C activators and heat shock.
DISEASE: SwissProt: P04792 # Defects in HSPB1 are the cause of Charcot-Marie-Tooth disease type 2F (CMT2F) [MIM:606595]. CMT2F is a form of Charcot- Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. CMT2F onset is between 15 and 25 years with muscle weakness and atrophy usually beginning in feet and legs (peroneal distribution). Upper limb involvement occurs later. CMT2F inheritance is autosomal dominant. & Defects in HSPB1 are a cause of distal hereditary motor neuropathy (dHMN) [MIM:608634]. Distal HMN is a pure motor peripheral neuropathy without sensory abnormalities.
SIMILARITY: SwissProt: P04792 ## Belongs to the small heat shock protein (HSP20) family.产品使用声明 质量保证 Routinely evaluated by immunoblot with cell lysate prepared from MCF-7 cells that were heat shocked for 30 minutes at 42°C, cultured for an additional 16 hours at 37°C, and then stimulated with 200μM arsenite for 30 minutes 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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