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merck millipore,默克密理博,182515,Arp2/3 Complex Inhibitor I, CK-666 - CAS 442633-00-3 - Calbiochem
产品名称：Arp2/3 Complex Inhibitor I, CK-666 - CAS 442633-00-3 - Calbiochem
产品型号：182515
The Arp2/3 Complex Inhibitor I, CK-666, also referenced under CAS 442633-00-3, controls the biological activity of Arp2/3. This small molecule/inhibitor is primarily used for Cell Structure applicatio More>>
merck millipore,默克密理博,182515,Arp2/3 Complex Inhibitor I, CK-666 - CAS 442633-00-3 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₈H₁₇FN₂O 442633-00-3 描述 概述 A cell-permeable indolyl-fluorobenzamide compound that selectively inhibits actin assembly mediated by actin-related protein Arp2/3 complex of human, bovine, fission yeast S. pombe, and budding yeast S. cerevisiae origin (IC50 = 4, 17, 5, and 12 µM, respectively), without affecting S. pombe formin domain Cdc12(FH2)-mediated or the spontaneous actin polymerization. Shown to inhibit the actin filament "comet tails" formation around intracellular Listeria in infected SKOV3 cells (IC50 = 7 µM) in a reversible manner. Structrual studies indicate that CK-666 targets a pocket formed between subdomain 4 of Arp2 and subdomain 1 of Arp3, preventing Arp2/3 from shifting into an active conformation upon N-WASP-VCA binding. CK-666 and CK-869 (Cat. No. 182516) exhibit different modes of binding, resulting in their different yeast cross-reactivities. CK-689 (Cat. No. 182517) can serve as a negative control. 产品目录编号 182515 品牌系列 Calbiochem®
同义词 Actin Assembly Inhibitor XIII, 2-Fluoro-N-(2-(2-Methyl-1H-indol-3-yl)ethyl)benzamide, CK-0944666 应用数据 
参考 参考 Nolen, B.J., et al. 2009. Nature 460, 1031. 产品信息 CAS号 442633-00-3 形式 Off-white solid Hill配方 C₁₈H₁₇FN₂O 化学配方 C₁₈H₁₇FN₂O Molar Mass 296.3 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Regulatory Review
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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