merck millipore,默克密理愽
  • merck millipore,默克密理博,05-536,Anti-IKKα Antibody, clone 14A231

  • merck millipore,默克密理博,05-536,Anti-IKKα Antibody, clone 14A231

    产品名称：Anti-IKKα Antibody, clone 14A231
    产品型号：05-536
    Anti-IKKα Antibody, clone 14A231 is an antibody against IKKα for use in WB.

    merck millipore,默克密理博,05-536,Anti-IKKα Antibody, clone 14A231

  • 产品介绍
  • merck millipore,默克密理博,05-536,Anti-IKKα Antibody, clone 14A231

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Mk, H, MWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-536
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-IKKα Antibody, clone 14A231
    产品信息
    格式 Purified
    控制
    • Positive Control Included: Jurkat cell lysate (12-303)
    演示 Protein G Purified immunoglobulin in Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
    应用
    应用 Anti-IKKα Antibody, clone 14A231 is an antibody against IKKα for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 His-tagged, full length human IKKα
    克隆 14A231
    宿主 Mouse
    特异性 Recognizes IKKα.
    同种型 IgG1
    品种反应性 MonkeyHumanMouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001278
    Entrez基因汇总 This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
    基因符号
    • IKK-alpha
    • CHUK
    • NFKBIKA
    • IKKA
    • IKBKA
    • IkBKA
    • TCF16
    • IKK1
    • IKK-A
    纯化方法 Protein G purfied
    UniProt编号
    • O15111
    UniProt汇总 FUNCTION: SwissProt: O15111 # Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B- regulated promoters during inflammatory responses triggered by cytokines.
    SIZE: 745 amino acids; 84654 Da
    SUBUNIT: Preferentially found as a heterodimer with IKK-beta but also as an homodimer. Directly interacts with IKK-gamma/NEMO and TRPC4AP (By similarity). Heterodimers form the active complex. The tripartite complex can also bind to MAP3K14/NIK, MEKK1, IKAP and IKB-alpha-p65-p50 complex. A weak interaction with TRAF2 cannot be excluded. Part of a complex composed of NCOA2, NCOA3, IKKB, IKBKG and CREBBP. Interacts with NALP2. May interact with MAVS/IPS1.
    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus.
    TISSUE SPECIFICITY: Widely expressed.
    PTM: Phosphorylated by MAP3K14/NIK, AKT and to a lesser extent by MEKK1, and dephosphorylated by PP2A. Autophosphorylated.
    SIMILARITY: SwissProt: O15111 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. IkappaB kinase subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from Jurkat cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-536,Anti-IKKα Antibody, clone 14A231

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