merck millipore,默克密理愽
  • merck millipore,默克密理博,17-229,Acetyl-Histone H4 Immunoprecipitation (ChIP) Assay Kit

  • merck millipore,默克密理博,17-229,Acetyl-Histone H4 Immunoprecipitation (ChIP) Assay Kit

    产品名称：Acetyl-Histone H4 Immunoprecipitation (ChIP) Assay Kit
    产品型号：17-229
    Acetyl-Histone H4 Immunoprecipitation (ChIP) Assay Kit used to immunoprecipitate transcriptionally active chromatin from mammalian cells using anti-Acetyl-Histone H4, ChIP grade rabbit antiserum.

    merck millipore,默克密理博,17-229,Acetyl-Histone H4 Immunoprecipitation (ChIP) Assay Kit

  • 产品介绍
  • merck millipore,默克密理博,17-229,Acetyl-Histone H4 Immunoprecipitation (ChIP) Assay Kit

    重要规格表

    主要应用
    IP
    描述
    产品目录编号 17-229
    品牌系列 Upstate
    商名
    • Upstate
    描述 Acetyl-Histone H4 Immunoprecipitation (ChIP) Assay Kit
    概述 For use to immunoprecipitate transcriptionally active chromatin from mammalian cells using anti-Acetyl-Histone H4, ChIP grade rabbit antiserum. Detection of the gene or promoter of interest in immunoprecipitated chromatin must be empirically determined by the researcher using quantitative PCR or Southern slot-blot analysis, using promotor specific primers or probe.
    产品信息
    部件
    • All necessary buffers
    • Anti-acetyl-Histone H4 (Cat.# 06-866)
    • Protein A agarose/Salmon Sperm DNA (Cat.# 16-157)
    应用
    应用 Acetyl-Histone H4 Immunoprecipitation (ChIP) Assay Kit used to immunoprecipitate transcriptionally active chromatin from mammalian cells using anti-Acetyl-Histone H4, ChIP grade rabbit antiserum.
    主要应用
    • Immunoprecipitation
    生物信息
    Entrez基因编号
    • NM_003538.3
    Entrez基因汇总 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
    基因符号
    • H4/E
    • HIST1H4A
    • H4/J
    • HIST1H4F
    • HIST1H4L
    • H4FN
    • H4FA
    • H4FH
    • HIST1H4H
    • H4F2
    • H4FM
    • H4/A
    • H4FK
    • H4FG
    • HIST2H4
    • H4FB
    • H4/K
    • HIST1H4I
    • H4/N
    • HIST1H4B
    • H4FE
    • H4/M
    • H4/a
    • HIST1H4E
    • HIST4H4
    • HIST2H4A
    • H4FC
    • H4FI
    • H4/H
    • HIST1H4C
    • H4/G
    • HIST1H4K
    • H4FJ
    • H4FD
    • H4/I
    • H4/B
    • H4/D
    • H4/C
    • HIST1H4J
    • HIST1H4D
    修改
    • Acetylation
    UniProt编号
    • P62805
    UniProt汇总 FUNCTION: SwissProt: P62805 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    SIZE: 103 amino acids; 11367 Da
    SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SUBCELLULAR LOCATION: Nucleus.
    PTM: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). & Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
    SIMILARITY: SwissProt: P62805 ## Belongs to the histone H4 family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 1 kit
    包装 Kit capacity: 22 assays

    merck millipore,默克密理博,17-229,Acetyl-Histone H4 Immunoprecipitation (ChIP) Assay Kit

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