merck millipore,默克密理博,16-318,Anti-Akt/PKB Antibody, PH Domain, clone SKB1, Magnetic Bead Conjugate

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	IP	M	Purified	Monoclonal Antibody

描述
产品目录编号	16-318
描述	Anti-Akt/PKB Antibody, PH Domain, clone SKB1, Magnetic Bead Conjugate
背景信息	Akt (protein kinase B), a serine/threonine kinase, has emerged as a critical enzyme in signal transduction pathways involved in cell proliferation, apoptosis, angiogenesis, and diabetes. In mammals three isoforms of Akt (α, β, γ or Akt 1, 2, 3) are reported that exhibit a high degree of homology, but differ slightly in the localization of their regulatory phosphorylation sites. Akt α is the predominant isoform in most tissues, whereas the highest expression of Akt β is observed in the insulin-responsive tissues, and Akt γ is abundant in brain tissue. Each Akt isoform is composed of three functionally distinct regions: an N-terminal pleckstrin homology (PH) domain that provides a lipid-binding module to direct Akt to PIP2 and PIP3, a central catalytic domain, and a C-terminal hydrophobic motif.

产品信息
格式	Purified
控制	NIH3T3 whole cell lysate stimulated with 50 ng/mL PDGF (5 minutes)
演示	20% slurry; 1X PBS, 0.05% sodium azide. Sufficient for 10 IPs.

应用
应用	Detect Akt/PKB using this Anti-Akt/PKB Antibody, PH Domain, clone SKB1, Magnetic Bead Conjugate validated for use in IP.
主要应用	Immunoprecipitation

生物信息
免疫原品种	GST-fusion protein corresponding to residues 1-149 of human Akt1
克隆	clone SKB1
宿主	Mouse
特异性	Recognizes Akt1/PKBα.
同种型	IgG
品种反应性	RatHumanMouse
Species Reactivity Note	Human, Mouse, Rat
抗体类型	Monoclonal Antibody
纯化方法	Protein G Chromatography

产品使用声明
质量保证	Evaluated by immunoprecipitation on 250 μg of NIH3T3 whole cell lysate stimulated with 50 ng/mL PDGF (5 minutes).
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8ºC from date of receipt.

包装信息
数量	200 µL

merck millipore,默克密理博,16-318,Anti-Akt/PKB Antibody, PH Domain, clone SKB1, Magnetic Bead Conjugate

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