merck millipore,默克密理愽
  • merck millipore,默克密理博,14-476M,Cdk7/Cyclin H/MAT1 (CAK complex) Protein, active, 250 µg

  • merck millipore,默克密理博,14-476M,Cdk7/Cyclin H/MAT1 (CAK complex) Protein, active, 250 µg

    产品名称：Cdk7/Cyclin H/MAT1 (CAK complex) Protein, active, 250 µg
    产品型号：14-476M
    Active complex of recombinant full length human Cdk7, containing a C-terminal His6-tag, recombinant full-length human Cyclin H untagged & recombinant full-length human MAT1 containing an N-terminal GS More>>

    merck millipore,默克密理博,14-476M,Cdk7/Cyclin H/MAT1 (CAK complex) Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-476M,Cdk7/Cyclin H/MAT1 (CAK complex) Protein, active, 250 µg

    描述
    产品目录编号 14-476M
    品牌系列 Upstate
    商名
    • Upstate
    描述 Cdk7/Cyclin H/MAT1 (CAK complex) Protein, active, 250 µg
    概述 Complex of recombinant full length human cdk7, containing a C-terminal His6-tag, recombinant full-length human cyclin H untagged and recombinant full-length human MAT1 containing an N-terminal GST-tag
    应用
    应用 Active complex of recombinant full length human Cdk7, containing a C-terminal His6-tag, recombinant full-length human Cyclin H untagged & recombinant full-length human MAT1 containing an N-terminal GST-tag, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 All are expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_001799.2
    Entrez基因汇总 The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
    基因符号
    • STK1
    • CDK7
    • p39MO15
    • CAK
    • CAK1
    • MO15
    • CDKN7
    蛋白靶 CDK7/cyclinH/MAT1
    纯化方法 Ni2+/NTA-agarose
    靶子系列 CMGC
    UniProt编号
    • P50613
    UniProt汇总 FUNCTION: SwissProt: P50613 # Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between two subsequent phases in the cell cycle. CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex, a serine-threonine kinase. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
    SIZE: 346 amino acids; 39038 Da
    SUBUNIT: Associates primarily with cyclin H and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor. Interacts with PUF60.
    SUBCELLULAR LOCATION: Nucleus.
    TISSUE SPECIFICITY: Ubiquitous.
    PTM: Phosphorylation of Ser-164 during mitosis inactivates the enzyme. & Phosphorylation of Thr-170 is required for activity.
    SIMILARITY: SwissProt: P50613 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of cdk7 substrate peptide
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -70°C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-476) and in bulk (cat# 14-476-K).

    merck millipore,默克密理博,14-476M,Cdk7/Cyclin H/MAT1 (CAK complex) Protein, active, 250 µg

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下一件merck millipore产品：merck millipore,默克密理博,SF-789,EPCAM; Human, Cyanine 5, RNA Detection Probe,SmartFlare


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