- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MABC112 Replaces MABE526 描述 Anti-RASSF1 Antibody, clone 5C9.1 Alternate Names - Ras association domain-containing protein 1
背景信息 RASSF1, also known as Ras association domain-containing protein 1, and encoded by the gene RASSF1/RDA32, is an important cell cycle and cell proliferation regulator protein. RASSF1 acts as a tumor suppressor and operates within the death receptor dependent apoptotic pathways. Additionally, RASSF1 inhibits proliferation at the G1/S boundary by regulating the accumulation of cyclin D1 protein. RASSF1 is localized to the cytoplasm and cytoskeleton depending upon cellular environment. RASSF1 localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. The protein also co-localizes with MDM2 in the nucleus. RASSF1 is expressed in multiple isoforms but in generally it is ubiquitously expressed but down regulated in cancer and tumor cells. 产品信息 格式 Purified 演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect RASSF1 using this Anti-RASSF1 Antibody, clone 5C9.1 validated for use in western blotting & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:50-500 dilution from a representative lot detected RASSF1 in human kidney and human prostate cancer tissue. 生物信息 免疫原品种 GST-tagged recombinant protein corresponding to human RASSF1. 克隆 5C9.1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG1κ 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_009113
基因符号 - RDA32
- RASSF1
纯化方法 Protein G purified UniProt编号 - Q9NS23
产品使用声明 质量保证 Evaluated by Western Blotting in human brain tissue lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected RASSF1 in 10 µg of human brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,14-627,EGFR (L861Q) Protein, active, 10 µg
下一件merck millipore产品：merck millipore,默克密理博,MABC98,Anti-Sphingosine 1-phosphate receptor 5 (S1P5) Antibody, clone 13F9.1
merck millipore,默克密理博,219427,Cathepsin L Inhibitor III - Calbiochem
merck millipore,默克密理博,MAB3068,Anti-Connexin 43 Antibody, CT
merck millipore,默克密理博,SF-191,miR-451a; Human, Cyanine 5, RNA Detection Probe,SmartFlare
merck millipore,默克密理博,401478,IκB Kinase Inactive Control Peptide, Cell-Permeable - Calbiochem
merck millipore,默克密理博,14-627,EGFR (L861Q) Protein, active, 10 µg
merck millipore,默克密理博,MABC98,Anti-Sphingosine 1-phosphate receptor 5 (S1P5) Antibody, clone 13F9.1
merck millipore,默克密理博,16-318,Anti-Akt/PKB Antibody, PH Domain, clone SKB1, Magnetic Bead Conjugate
merck millipore,默克密理博,04-642,Anti-Ago2 Antibody, clone 9E8.2
merck millipore,默克密理博,14-476M,Cdk7/Cyclin H/MAT1 (CAK complex) Protein, active, 250 µg
merck millipore,默克密理博,SF-789,EPCAM; Human, Cyanine 5, RNA Detection Probe,SmartFlare