merck millipore,默克密理博,149101,1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8

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merck millipore,默克密理博,149101,1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem
产品名称：1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem
产品型号：149101
An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.

merck millipore,默克密理博,149101,1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem

产品介绍

merck millipore,默克密理博,149101,1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem

重要规格表

经验配方	CAS号
C₄H₇NO₂	22059-21-8

描述
概述	An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Mimics the effects of glycine on the NMDA receptor ion channel and blocks ³H-glycine binding to rat forebrain membrane (IC₅₀ = 38 nM). Blocks NMDA-induced release of arachidonic acid (IC₅₀ = 131 µM) in cerebellar granule cells. Reduces NMDA-induced cell death in hippocampal neurons.
产品目录编号	149101
品牌系列	Calbiochem®
同义词	ACPC

参考
参考	Viu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527. Zapata, A., et al. 1996. NeuroReport 7, 397. Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393. Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937. Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992. Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115. Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.

参考

Viu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
Zapata, A., et al. 1996. NeuroReport 7, 397.
Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.

产品信息
CAS号	22059-21-8
具有ATP竞争性	N
形式	Crystalline solid
Hill配方	C₄H₇NO₂
化学配方	C₄H₇NO₂
Molar Mass	101.1
可逆	N
结构配方图像

生物信息
主靶	Glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex
主靶IC₅₀	38 nM in blocking 3H-glycine binding to rat forebrain membrane; 131 µM in blocking NMDA-induced release of arachidonic acid; 131 µM in cerebellar granule cells
纯度	≥ 98% by TLC

理化信息
细胞可渗透	N
溶解度	H₂O

GHS安全信息
RTECS	GZ1110000

安全信息
R相	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S相	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Irritant
储存	+15°C to +30°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.