merck millipore,默克密理博,04-360,Anti-GSK3 alpha Antibody, clone EP793Y, rabbit monoclonal

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merck millipore,默克密理博,04-360,Anti-GSK3 alpha Antibody, clone EP793Y, rabbit monoclonal
产品名称：Anti-GSK3 alpha Antibody, clone EP793Y, rabbit monoclonal
产品型号：04-360
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Less<<

merck millipore,默克密理博,04-360,Anti-GSK3 alpha Antibody, clone EP793Y, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-360,Anti-GSK3 alpha Antibody, clone EP793Y, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	ICC, WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	04-360
描述	Anti-GSK3 alpha Antibody, clone EP793Y, rabbit monoclonal
Alternate Names	glycogen synthase kinase-3 alpha glycogen synthase kinase 3 alpha
背景信息	Glycogen synthases kinase 3 alpha (GSK3-Alpha) is a multifunctional Serine/Threonine protein kinase, one of two isoforms of GSK3 (1). Originally identified as a regulator of glycogen synthase, it has been shown to be involved in the hormonal control of several regulatory factors and transcription factors. GSK3-Alpha activity is down regulated by phosphorylation on Serine 21 by PKB, or activated by phosphorylation on Tyrosine 279 (2). Insulin inactivates GSK3-Alpha by rapid phosphorylation which leads to activation of Glycogen Synthase in the cells (3). GSK3-Alpha activity has been linked to a pathogenic mechanism in Alzheimer's disease (4).

产品信息
格式	Unpurified
控制	HeLa cell lysate
演示	Rabbit Monoclonal in buffer containing glycerol, BSA, and sodium azide.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.
主要应用	Immunocytochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A 1:50-100 dilution from a representative lot was used in breast carcinoma tissue. Immunocytochemistry Analysis: A 1:50-100 dilution from a representative lot was used in IC. Immunoprecipitation Analysis: A 1:50 dilution from a representative lot was used in IP.

生物信息
免疫原品种	Synthetic peptide corresponding to the N-terminus of human GSK3 alpha.
表位	N-terminus
克隆	EP793Y
宿主	Rabbit
特异性	This antibody recognizes the N-terminus of GSK3 alpha.
同种型	IgG
品种反应性	RatHumanMouse
抗体类型	Monoclonal Antibody
Entrez基因编号	P49840
基因符号	EC 2.7.11 GSK-3 alpha EC 2.7.11.26 DKFZp686D0638 OTTHUMP00000198366 OTTHUMP00000198367 OTTHUMP00000198368
纯化方法	Unpurified
UniProt编号	P49840

产品使用声明
质量保证	Evaluated by Western Blot in HeLa cell lysate WesternBlot Analysis: A 1:5,000 dilution of this antibody detected GSK3 alpha in HeLa cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20ºC. Avoid freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20ºC. Avoid freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.