merck millipore,默克密理愽
  • merck millipore,默克密理博,04-585,Anti-Desmin Antibody, rabbit monoclonal, clone Y66

  • merck millipore,默克密理博,04-585,Anti-Desmin Antibody, rabbit monoclonal, clone Y66

    产品名称：Anti-Desmin Antibody, rabbit monoclonal, clone Y66
    产品型号：04-585
    Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-Desmin Antibody, Rabbit, clone Y66 detects leve More>>

    merck millipore,默克密理博,04-585,Anti-Desmin Antibody, rabbit monoclonal, clone Y66

  • 产品介绍
  • merck millipore,默克密理博,04-585,Anti-Desmin Antibody, rabbit monoclonal, clone Y66

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-585
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Desmin Antibody, rabbit monoclonal, clone Y66
    背景信息 Desmin are class-III intermediate filaments found in muscle cells, and are expressed during the formation of muscle cells or fibers. Cytoskeletal intermediate filaments (IFs) are constructed from two-chain alpha-helical coiled-coil molecules arranged on an imperfect helical lattice (1,2). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Desmin mutations have been linked to familial cardiac and skeletal myopathy (3,4).
    产品信息
    格式 Purified
    演示 Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
    应用
    应用 Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-Desmin Antibody, Rabbit, clone Y66 detects level of Desmin & has been published & validated for use in WB, IH(P).
    主要应用
    • Western Blotting
    应用说明 WB: 1:500
    IHC: 1:500 (Paraffin-embedded human heart muscle)
    生物信息
    免疫原品种 A synthetic peptide corresponding to C-terminus of human Desmin. Predicted to cross-react with rat, bovine and pig, based on sequence homology.
    克隆 Y66
    宿主 Rabbit
    特异性 Recognizes Human, Mouse, Rat Desmin.
    品种反应性 RatHumanMouse
    Species Reactivity Note Positive control: Mouse heart tissue.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001927.3
    Entrez基因汇总 This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.
    基因符号
    • desmin
    • DES
    • CSM2
    • FLJ41013
    • FLJ39719
    • CSM1
    • FLJ41793
    • FLJ12025
    • Desmin.
    • CMD1I
    纯化方法 Protein A purfied
    UniProt编号
    • P17661
    UniProt汇总 FUNCTION: SwissProt: P17661 # Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
    SIZE: 470 amino acids; 53536 Da
    SUBUNIT: Homopolymer.
    SUBCELLULAR LOCATION: Cytoplasm.
    DISEASE: SwissProt: P17661 # Defects in DES are the cause of desmin-related cardio- skeletal myopathy (CSM) [MIM:601419]; also known as desmin-related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells. A desmin-related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). & Defects in DES are the cause of dilated cardiomyopathy 1I (CMD1I) [MIM:604765]. CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function.
    SIMILARITY: SwissProt: P17661 ## Belongs to the intermediate filament family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at -20 °C. Stable for 12 months from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-585,Anti-Desmin Antibody, rabbit monoclonal, clone Y66

上一件merck millipore产品：merck millipore,默克密理博,04-360,Anti-GSK3 alpha Antibody, clone EP793Y, rabbit monoclonal
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