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描述 产品目录编号 14-922M 商名 - Upstate
描述 TrkC, active 概述 TrkC is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense
body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.产品信息 演示 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol 应用 主要应用 - Kinase Assay
生物信息 来源 N-terminal GST-tagged and C-terminal 6His-tagged, recombinant, human TrkC amino acids 510-end, expressed by baculovirus in Sf21 insect cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_002530
基因符号 - Trk-C
- TRKC
- NTRK3
纯化方法 Purified using glutathione agarose followed by gel filtration. 靶子系列 TK UniProt编号 - Q16288
产品使用声明 质量保证 Routinely evaluated by phosphorylation of GEEPLYWSFPAKKK 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C 包装信息 数量 250 µg 包装 Also available in 10μg size as catalog # 14-922 and in bulk as catalog # 14-922-K.
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