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merck millipore,默克密理博,05-446,Anti-p75NTR (Neurotrophin Receptor) Antibody, clone ME20.4
产品名称：Anti-p75NTR (Neurotrophin Receptor) Antibody, clone ME20.4
产品型号：05-446
Anti-p75NTR (Neurotrophin Receptor) Antibody, clone ME20.4 detects level of p75NTR (Neurotrophin Receptor) & has been published & validated for use in IP, WB, IH, NEUT.
merck millipore,默克密理博,05-446,Anti-p75NTR (Neurotrophin Receptor) Antibody, clone ME20.4
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Mk, H IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-446 Replaces 04-1111 品牌系列 Upstate
商名 - Upstate
描述 Anti-p75NTR (Neurotrophin Receptor) Antibody, clone ME20.4 Alternate Names - NGFR
- p75 Low Affinity Neurotrophin Receptor
产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-p75NTR (Neurotrophin Receptor) Antibody, clone ME20.4 detects level of p75NTR (Neurotrophin Receptor) & has been published & validated for use in IP, WB, IH, NEUT. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 Human melanoma cell line WM245. 克隆 A16/17 宿主 Mouse 特异性 low affinity p75NTR 同种型 IgG1 品种反应性 MonkeyHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002507
Entrez基因汇总 Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. 基因符号 - TNFRSF16
- NGFR
- Gp80-LNGFR
- CD271
- p75(NTR)
纯化方法 Protein G chromatography UniProt编号 - P08138
UniProt汇总 FUNCTION: SwissProt: P08138 # Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
SIZE: 427 amino acids; 45183 Da
SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DOMAIN: SwissProt: P08138 Death domain is responsible for interaction with RANBP9.
PTM: N- and O-glycosylated. & O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. & Phosphorylated on serine residues.
SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from HS294T cells 销售限制 Due to license agreement restrictions, this product cannot be purchased for resale. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 100 µg
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