merck millipore,默克密理愽
  • merck millipore,默克密理博,07-326,Anti-phospho-Cofilin 2 (Ser3) Antibody

  • merck millipore,默克密理博,07-326,Anti-phospho-Cofilin 2 (Ser3) Antibody

    产品名称：Anti-phospho-Cofilin 2 (Ser3) Antibody
    产品型号：07-326
    Anti-phospho-Cofilin 2 (Ser3) Antibody detects level of phospho-Cofilin 2 (Ser3) & has been published & validated for use in WB.

    merck millipore,默克密理博,07-326,Anti-phospho-Cofilin 2 (Ser3) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-326,Anti-phospho-Cofilin 2 (Ser3) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, Ch, HWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 07-326
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-Cofilin 2 (Ser3) Antibody
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Anti-phospho-Cofilin 2 (Ser3) Antibody detects level of phospho-Cofilin 2 (Ser3) & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 peptide corresponding to amino acids 1-10 (MA[pS]GVTVNDE-C) of human phospho-Cofilin 2
    宿主 Rabbit
    特异性 phospho-Cofilin 2
    同种型 IgG
    品种反应性 MouseChickenHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_021914
    Entrez基因汇总 Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. (Gillett et al., 1996 [PubMed 8800436]). Cofilin-2 is a member of the AC group of proteins that also includes cofilin-1 (CFL1) and destrin (DSTN; MIM 609114), all of which regulate actin-filament dynamics (Bamburg et al., 1999 [PubMed 10461190]; Maciver and Hussey, 2002). The CFL2 gene encodes a skeletal muscle-specific isoform (Vartiainen et al., 2002 [PubMed 11809832]) localized to the thin filaments, where it exerts its effect on actin, in part through interactions with tropomyosins (Ono and Ono, 2002 [PubMed 11901171]).[supplied by OMIM]
    基因符号
    • Cofilin-2
    • CFL2
    • NEM7
    修改
    • Phosphorylation
    纯化方法 Protein A chromatography
    UniProt编号
    • Q9Y281
    UniProt汇总 FUNCTION: SwissProt: Q9Y281 # Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity).
    SIZE: 166 amino acids; 18737 Da
    SUBCELLULAR LOCATION: Nucleus matrix (By similarity). Cytoplasm, cytoskeleton (By similarity).
    TISSUE SPECIFICITY: Isoform CFL2b is expressed predominantly in skeletal muscle and heart, while isoform CFL2a is expressed in various tissues.
    PTM: The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.
    DISEASE: SwissProt: Q9Y281 # Defects in CFL2 are the cause of nemaline myopathy type 7 (NEM7) [MIM:610687]. Nemaline myopathy (NEM) is a form of congenital myopathy characterized by abnormal thread- or rod-like structures in muscle fibers on histologic examination. The clinical phenotype is highly variable, with differing age at onset and severity.
    SIMILARITY: SwissProt: Q9Y281 ## Belongs to the actin-binding proteins ADF family. & Contains 1 ADF-H domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from L6 cells, treated with LIM Kinase
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µg

    merck millipore,默克密理博,07-326,Anti-phospho-Cofilin 2 (Ser3) Antibody

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