merck millipore,默克密理愽
  • merck millipore,默克密理博,14-792M,PI 3-Kinase (p110α(H1047R)/p85α), 250 µg

  • merck millipore,默克密理博,14-792M,PI 3-Kinase (p110α(H1047R)/p85α), 250 µg

    产品名称：PI 3-Kinase (p110α(H1047R)/p85α), 250 µg
    产品型号：14-792M
    Complex of N-terminal 6His-tagged recombinant human p110α full length, containing the mutation H1047R & untagged, recombinant, human p85α full length.

    merck millipore,默克密理博,14-792M,PI 3-Kinase (p110α(H1047R)/p85α), 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-792M,PI 3-Kinase (p110α(H1047R)/p85α), 250 µg

    描述
    产品目录编号 14-792M
    品牌系列 Upstate
    商名
    • Upstate
    描述 PI 3-Kinase (p110α(H1047R)/p85α), 250 µg
    概述 Complex of N-terminal 6His-tagged recombinant human p110α full length, containing the mutation H1047R, and untagged, recombinant, human p85α full length.
    背景信息 The H1047R substitution is a somatic mutation in p110α that has been associated with tumours of the colon, stomach, breast and brain. Combined in vitro and in vivo studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation. (Samuels Y. et al., Science, (2004); 304: 554; Kang S. et al., PNAS, (2005);102: 802-807 and Zhao J.J. et al., PNAS, (2005);102:18443-18448).
    产品信息
    演示 50 mM Tris/HCl pH8.0, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 0.2 mM PMSF, 1 mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.
    应用
    应用 Complex of N-terminal 6His-tagged recombinant human p110α full length, containing the mutation H1047R & untagged, recombinant, human p85α full length.
    生物信息
    来源 Co-expressed by baculovirus in Sf21 insect cells.
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • U79143
    基因符号
    • PK3CA
    • PIK3CA
    • PI3K
    蛋白靶 PI3Kα/p85α
    纯化方法 Ni2+/NTA-agarose
    靶子系列 PI3K/PI4K
    UniProt编号
    • P42337 / P26450 (mouse)
    • P42336 / P27986
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-792) and in bulk (cat# 14-792-K).

    merck millipore,默克密理博,14-792M,PI 3-Kinase (p110α(H1047R)/p85α), 250 µg

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