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  • merck millipore,默克密理博,AB9274-200UL,Anti-Sodium Channel Nav1.8 Antibody, pain

  • merck millipore,默克密理博,AB9274-200UL,Anti-Sodium Channel Nav1.8 Antibody, pain

    产品名称：Anti-Sodium Channel Nav1.8 Antibody, pain
    产品型号：AB9274-200UL
    This Anti-Sodium Channel Nav1.8 Antibody, pain is validated for use in WB for the detection of Sodium Channel Nav1.8.

    merck millipore,默克密理博,AB9274-200UL,Anti-Sodium Channel Nav1.8 Antibody, pain

  • 产品介绍
  • merck millipore,默克密理博,AB9274-200UL,Anti-Sodium Channel Nav1.8 Antibody, pain

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB9274-200UL
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Sodium Channel Nav1.8 Antibody, pain
    Alternate Names
    • SNS, SCN10A, PN3
    • SNS
    • SCN10A
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
    应用
    应用 This Anti-Sodium Channel Nav1.8 Antibody, pain is validated for use in WB for the detection of Sodium Channel Nav1.8.
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:200 using ECL on rat DRG lysate.

    Dilutions should be made using a carrier protein such as BSA (1-3%)

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide from rat Nav1.8 (Accession Q63554). The immunogen sequence is 14/15 residues identical in mouse and 7/15 residues identical in human.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Nav1.8 (SNS, SCN10A, PN3)
    品种反应性 Rat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_006514.2
    Entrez基因汇总 Voltage-gated sodium channels are integral membrane glycoproteins that are responsible for the initial rising phase of action in most excitable cells. They are composed of a large alpha subunit that may be associated with one or more smaller beta subunits. Sodium channels can be differentiated by their primary structure, kinetics, and relative sensitivity to the neurotoxin tetrodotoxin (TTX). Sodium channels, particularly those with TTX-resistant currents, have been found to accumulate in the region of peripheral nerve injury and may be important in chronic pain. SCN10A encodes a TTX-resistant channel that is restricted to the peripheral sensory nervous system (Rabert et al., 1998 [PubMed 9839820]).[supplied by OMIM]
    基因符号
    • hPN3
    • SCN10A
    • PN3
    • Nav1.8
    • SNS
    UniProt编号
    • Q9Y5Y9
    UniProt汇总 FUNCTION: SwissProt: Q9Y5Y9 # This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms (By similarity).
    SIZE: 1956 amino acids; 220566 Da
    SUBUNIT: The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B. Found in a number of complexes with PRX, TCTEL1 and PDZK3. Interacts with proteins such as FSTL1, PRX, TCTEL1, PDZK3, S100A10 and many others (By similarity). Interacts with NEDD4 and NEDD4L.
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By similarity). Note=It can be translocated to the extracellular membrane through association with S100A10 (By similarity).TISSUE SPECIFICITY: Expressed in the dorsal root ganglia and sciatic nerve.
    DOMAIN: SwissProt: Q9Y5Y9 The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
    PTM: Ubiquitinated by NEDD4L; which promotes its endocytosis (By similarity).
    SIMILARITY: Belongs to the sodium channel family. & Contains 1 IQ domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,AB9274-200UL,Anti-Sodium Channel Nav1.8 Antibody, pain

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