merck millipore,默克密理愽
  • merck millipore,默克密理博,14-685,Cdk9/Cyclin T1 Protein, active, 10 µg

  • merck millipore,默克密理博,14-685,Cdk9/Cyclin T1 Protein, active, 10 µg

    产品名称：Cdk9/Cyclin T1 Protein, active, 10 µg
    产品型号：14-685
    Active, C-terminal 6His-tagged, full length recombinant, human Cdk9 co-expressed with untagged, full-length human Cyclin T1, for use in Kinase Assays.

    merck millipore,默克密理博,14-685,Cdk9/Cyclin T1 Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-685,Cdk9/Cyclin T1 Protein, active, 10 µg

    描述
    产品目录编号 14-685
    品牌系列 Upstate
    商名
    • Upstate
    描述 Cdk9/Cyclin T1 Protein, active, 10 µg
    概述 C-terminal 6His-tagged, fulllength recombinant, human cdk9 co-expressed with untagged, full-length human cyclin T1
    应用
    应用 Active, C-terminal 6His-tagged, full length recombinant, human Cdk9 co-expressed with untagged, full-length human Cyclin T1, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_001261.2
    Entrez基因汇总 The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.
    基因符号
    • C-2K
    • CDK9
    • C-2k
    • PITALRE
    • TAK
    • CDC2L4
    蛋白靶 CDK9/cyclin T1
    纯化方法 Ni2+/NTA-agarose
    靶子系列 CMGC
    UniProt编号
    • P50750
    UniProt汇总 FUNCTION: SwissProt: P50750 # Member of the cyclin-dependent kinase pair (CDK9/cyclin- T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II), SUPT5H and RDBP. The CDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitro.
    SIZE: 372 amino acids; 42778 Da
    SUBUNIT: Associates with CCNT1/cyclin-T1 to form P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31. Also associates with CCNK/cyclin-K. Component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and NCL/nucleolin. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs.
    SUBCELLULAR LOCATION: Nucleus.
    TISSUE SPECIFICITY: Ubiquitous.
    SIMILARITY: SwissProt: P50750 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of PDKtide (Catalog# 12-401)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 stable for 6 months at -70°C from date of shipment
    包装信息
    数量 10 µg

    merck millipore,默克密理博,14-685,Cdk9/Cyclin T1 Protein, active, 10 µg

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